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Single-copy Loss of Rho Guanine Nucleotide Exchange Factor 10 (arhgef10) Causes Locomotor Abnormalit
[期刊论文] 作者：ZHANG Yi,AN Ming Xing,GONG Chen,LI Yang Yang,WANG Yu Tong,LIN Meng,LI Rong,TIAN Chan,
来源：生物医学与环境科学（英文版） 年份：2022
Objective To determine if ARHGEF10 has a haploinsufficient effect and provide evidence to evaluate the severity, if any, during prenatal consultation. Methods Zebrafish was used as a model for generating mutant. The pattern of arhgef10 expr......
The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin B1 (ITGB1
[期刊论文] 作者：Hai-Yang Ma,Yan Xu,Chun-You Qiao,Yi Peng,Qi Ding,Li-Zhong Wang,Jun-Fei Yan,Yuan Hou,Fei Di,
来源： 年份：2022
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[期刊论文] 作者：Zhangsen Chen,Gaixia Zhang,Yuren Wen,Ning Chen,Weifeng Chen,Tom Regier,James Dynes,Yi Zheng,Shuhui Sun,
来源：纳微快报（英文版） 年份：2022
The electroreduction reaction of CO2 (ECO2RR) requires high-performance catalysts to convert CO2 into useful chemicals.Tran-sition metal-based atomically dispersed catalysts are promising for the high selectivity and activity in ECO2RR.This......
Safety and efficacy of anti-EGFR monoclonal antibody (SCT200) as second-line therapy in advanced eso
[期刊论文] 作者：Ming Bai,Meng Wang,Ting Deng,Yuxian Bai,Kai Zang,Zhanhui Miao,Wenlin Gai,Liangzhi Xie,Yi Ba,
来源：癌症生物学与医学（英文版） 年份：2022
Objective: The mainstay treatment of esophageal squamous cell carcinoma (ESCC) involves chemotherapy and immunotherapy. However, alternative therapies are required for patients who are refractory or intolerant to existing therapies. Methods......
Multiscale design and biomechanical evaluation of porous spinal fusion cage to realize specified mec
[期刊论文] 作者：Hongwei Wang,Yi Wan,Quhao Li,Xinyu Liu,Mingzhi Yu,Xiao Zhang,Yan Xia,Qidong Sun,Zhanqiang Liu,
来源：生物设计与制造（英文版） 年份：2022
Background Dense titanium(Ti)fusion cages have been commonly used in transforaminal lumbar interbody fusion.However,the stiffness mismatch between cages and adjacent bone endplates increases the risk of stress shielding and cage subsidence.......
[期刊论文] 作者：NIE Yuanyuan,XIA Hui,MA Xiaosong,LOU Qiaojun,LIU Yi,ZHANG Anling,CHENG Liang,YAN Longan,LUO Lijun,
来源：水稻科学（英文版） 年份：2022
Deep rooting is an important trait in rice drought resistance. Genetic resources of deep-rooting varieties are valuable in breeding of water-saving and drought-resistant rice. In the present study, 234 BC2F7 backcross introgression lines we......
[期刊论文] 作者：Lin Zhao,Yuan Hao,Li Chen,Wenyi Liu,Meng Jin,Yi Wu,Jiamin Tao,Kaiqian Jie,Hongzhan Liu,
来源：中国光学快报（英文版） 年份：2022
Vortex optical communication has been a hot research field in recent years.A key step is mode recognition in the orbital angular momentum[OAM]free-space optical[FSO]communication system.In this article,we propose an OAM mode rec-ognition me......
Artificial intelligence computed tomography helps evaluate the severity of COVID-19 patients: A retr
[期刊论文] 作者：Yi Han,Su-cheng Mu,Hai-dong Zhang,Wei Wei,Xing-yue Wu,Chao-yuan Jin,Guo-rong Gu,Bao-jun Xie,Chao-yang,
来源：世界急诊医学杂志（英文版） 年份：2022
BACKGROUND: Computed tomography (CT) is a noninvasive imaging approach to assist the early diagnosis of pneumonia. However, coronavirus disease 2019 (COVID-19) shares similar imaging features with other types of pneumonia, which makes diffe......
Ultrasmall Pt2Sr alloy nanoparticles as efficient bifunctional electrocatalysts for oxygen reduction
[期刊论文] 作者：Xiangnan Liu,Shaoyun Hao,Guokui Zheng,Zhiwei Su,Yahui Wang,Qiqi Wang,Lecheng Lei,Yi He,Xingwang Zhang,
来源：能源化学 年份：2022
Electrocatalytic oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) in acidic media are vital for the applications of renewable energy electrolyzers.However,the low mass activity of noble Pt urgently needs to be improved ......
[期刊论文] 作者：Jiamou Ren,Shuli Zhang,Xiaoling Wang,Yuxin Deng,Yi Zhao,Yan Xiao,Jian Liu,Liangzhao Chu,Xiaolan Qi,
来源：生物化学与生物物理学报（英文版） 年份：2022
Myocyte enhancer factor 2C(MEF2C)is highly expressed in the nervous system,and regulates neuro-development,synaptic plasticity,and inflammation.However,its mechanism in Alzheimer\'s disease(AD)is underestimated.In this study,the role and me......
Mismatch between the population and meltwater changes creates opportunities and risks for global gla
[期刊论文] 作者：Bo Su,Cunde Xiao,Deliang Chen,Xue Ying,Yi Huang,Rong Guo,Hongyu Zhao,Aifang Chen,Yanjun Che,
来源：科学通报（英文版） 年份：2022
Mountain glaciers are indispensable suppliers of freshwater for human sustenance in extensive cold and arid areas of the world [1-3].However,due to pronounced climate change over the last dec-ades,the vast majority of the world\'s mountains......
[期刊论文] 作者：Hui-Jun Mu,Wei-Min Gu,Tuan Yi,Ling-Lin Zheng,Hao Sou,Zhong-Rui Bai,Hao-Tong Zhang,Ya-Juan Lei,Cheng-Ming,
来源：中国科学：物理学 力学 天文学（英文版） 年份：2022
Searching for compact objects(black holes,neutron stars,or white dwarfs)in the Milky Way is essential for understanding the stellar evolution history,the physics of compact objects,and the structure of our Galaxy.Compact objects in binaries......
[期刊论文] 作者：Yuan Zhu,Yi Huang,Jin Yang,Rong Tu,Xin Zhang,Wei-Wei He,Chang-Yue Hou,Xiao-Ming Wang,Ju-Ming Yu,Guo-Hui,
来源：中国神经再生研究（英文版） 年份：2022
In Alzheimer\'s disease and ischemic stroke, intranasal insulin can act as a neuroprotective agent. However, whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanisms remain poorly unde......
[期刊论文] 作者：Dawei Li,Xiaoyue Lu,Yanhui Zhu,Jun Pan,Shaoqun Zhou,Xinyan Zhang,Guangtao Zhu,Yi Shang,Sanwen Huang,Chunzhi,
来源：植物学报（英文版） 年份：2022
Heterosis is a fundamental biological phenomenon characterized by the superior performance of hy-brids over their parents. Although tremendous progress has been reported in seed crops, the molecular mechanisms underlying heterosis in clonal......
Regulation of cytokinin biosynthesis using PtRD26pro-IPT module improves drought tolerance through P
[期刊论文] 作者：Hou-Ling Wang,Qi Yang,Shuya Tan,Ting Wang,Yi Zhang,Yanli Yang,Weilun Yin,Xinli Xia,Hongwei Guo,Zhonghai,
来源：植物学报（英文版） 年份：2022
Drought is a critical environmental factor which constrains plant survival and growth. Genetic en-gineering provides a credible strategy to improve drought tolerance of plants. Here, we generated transgenic poplar lines expressing the isope......
[期刊论文] 作者：Wenyuan Ruan,Yibo Zhang,Yuxin Zhang,Xueqing Wang,Zhenhui Guo,Long Wang,Tian Zhou,Javier Paz-Ares,Keke Yi,
来源：分子植物（英文版） 年份：2022
Phosphorous (P) and iron (Fe),two essential nutrients for plant growth and development,are highly abundant elements in the earth\'s crust but often display low availability to plants.Due to the ability to form insoluble complexes,the antago......
[期刊论文] 作者：Lan Lu,Mingxing Li,Guojuan Yi,Li Liao,Qiang Cheng,Jie Zhu,Bin Zhang,Yingying Wang,Yong Chen,Ming Zeng,
来源：药物分析学报（英文版） 年份：2022
Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two decades,a novel series of s......
Oncolytic Activity of Wild-type Newcastle Disease Virus HK84 Against Hepatocellular Carcinoma Associ
[期刊论文] 作者：Liming Chen,Yongdong Niu,Jiating Sun,Hong Lin,Guoxi Liang,Min Xiao,Dongmei Shi,Jia Wang,Huachen Zhu,Yi,
来源：临床与转化肝病杂志（英文版） 年份：2022
Background and Aims: Hepatocellular carcinoma (HCC) is listed as one of the most common causes of cancer-related death. Oncolytic therapy has become a promising treatment because of novel immunotherapies and gene editing tech-nology, but bi......
Generation of a high-efficiency adenine base editor with TadA8e for developing wheat dinitroaniline-
[期刊论文] 作者：Huanan Han,Ziwen Wu,Ling Zheng,Jingyi Han,Yi Zhang,Jihu Li,Shujuan Zhang,Genying Li,Changle Ma,Pingping,
来源：作物学报（英文版） 年份：2022
Base editing using CRISPR technologies is an invaluable tool for crop breeding.One of the major base edi-tors,the adenine base editor(ABE),has been successfully used in both model plants and many crops.However,owing to limited editing effic......
[期刊论文] 作者：Lin Ma,Yanhua Du,Xiangjie Xu,Hexi Feng,Yi Hui,Nan Li,Guanyu Jiang,Xiaoqing Zhang,Xiaocui Li,Ling Liu,
来源：神经科学通报（英文版） 年份：2022
Congenital hydrocephalus is a major neurolog-ical disorder with high rates of morbidity and mortality;however,the underlying cellular and molecular mecha-nisms remain largely unknown.Reproducible animal models mirroring both embryonic and p......
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