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[期刊论文] 作者：Nana Fan,Liangxue Lai,,
来源：遗传学报 年份：2013
Genetically modified animal models are important for understanding the pathogenesis of human disease and developing therapeutic strategies.Although genetically...
[期刊论文] 作者：Zhiquan Liu,Siyu Chen,Yingqi Jia,Huanhuan Shan,Mao Chen,Yuning Song,Liangxue Lai,Zhanjun Li,
来源：中国科学:生命科学英文版 年份：2021
Cytidine base editor(CBE),which is composed of a cytidine deaminase fused to Cas9 nickase,has been widely used to induce C-to-T conversions in a wide range of organisms.However,the targeting scope of current CBEs is largely restricted to pr......
A tunable,rapid,and precise drug control of protein expression by combining transcriptional and post
[期刊论文] 作者：Li Li,Hongyi Meng,Jianmin Zhang,Yang Liu,Qingjian Zou,Yi Gao,Huaqiang Yang,Liangxue Lai,
来源：遗传学报 年份：2020
Rapid,precise,and tunable regulation of protein abundance would be significantly useful in a variety of biotechnologies and biomedical applications.Here,we desc...
Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst comp
[期刊论文] 作者：Zhang,Shixue Gou,Pengfei Chen,Lisha Mou,Nana Fan,Yangyang Suo,Zhen Ouyang,Chengdan Lai,Quanmei Yan,Liangxue Lai,
来源：遗传学报 年份：2020
Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells...
Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A va
[期刊论文] 作者：Shi,Yanhui Liang,Jingke Xie,Weikai Ge,Zhenpeng Zhuang,Jiaowei Wang,Yinghua Ye,Yi Yang,Kepin Wang,Liangxue Lai,
来源：遗传学报 年份：2021
Base editor-mediated C-to-T base conversion obviates the re-quirements of double-strand breaks,thereby showing promise as a tool for disease modeling and gene t...
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