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[期刊论文] 作者：Yelei Guo,Weidong Han,,
来源：Chinese Journal of Cancer 年份：2015
The accumulation of basic researches and clinical studies related to cytokine-induced killer(CIK) cells has confirmed their safety and feasibility in treating m...
[期刊论文] 作者：Yelei Guo,Weidong Han,
来源：黑龙江科技学院学报 年份：2015
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7...
[期刊论文] 作者：Jianshu Wei,Weidong Han,,
来源：Science China(Life Sciences) 年份：2017
For a long time,unresectable tumors were mainly controlled by chemotherapy,radiation therapy or kinase inhibitors,with which complete and durable remission was...
[期刊论文] 作者：Weidong Han,Xiaobing Fu,
来源：中国科学：生命科学英文版 年份：2016
The use of translational medicine in Chinese hospitals appears to have become easier over the last decade.Products developed in the laboratory can sometimes...
[期刊论文] 作者：Yelei Guo,Weidong Han,,
来源：Chinese Journal of Cancer 年份：2015
Cytokine-induced killer(CIK)cells belong to a heterogeneous cell population that was first discovered in the 1990s and can be generated from lymphocytes co-cult...
[期刊论文] 作者：Zhenguang Wang,Yelei Guo,Weidong Han,
来源：蛋白质与细胞 年份：2017
Chimeric antigen receptor (CAR) is a recombinant immunoreceptor combining an antibody-derived targeting fragment with signaling domains capable of activating ce...
[期刊论文] 作者：Can Luo,Jianshu Wei,Weidong Han,,
来源：Science China(Life Sciences) 年份：2016
T cell mediated adoptive immune response has been characterized as the key to anti-tumor immunity. Scientists around the world including in China, have been try...
,Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and cu
[期刊论文] 作者：Yelei Guo,Kaichao Feng,Yao Wang,Weidong Han,
来源：蛋白质与细胞 年份：2018
Cancer stem cells (CSCs),a subpopulation of tumor cells,have self-renewal and multi-lineage differentiation abilities that play an important role in cancer init...
[期刊论文] 作者：Dongdong Ti,Haojie Hao,Xiaobing Fu,Weidong Han,,
来源：Science China(Life Sciences) 年份：2016
Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration.However,it remains challenging...
[期刊论文] 作者：Zhitao Gao,Chuan Tong,Yao Wang,Deyun Chen,Zhiqiang Wu,Weidong Han,
来源：遗传学报 年份：2019
Chimeric antigen receptor T-cell (CAR T) therapy is a kind of effective cancer immunotherapy.However,designing CARs remains a challenge because many targetable...
[期刊论文] 作者：Xiaohui Wang,Zhiqiang Wu,Wei Qiu,Ping Chen,Xiang Xu,Weidong Han,
来源：医学前沿 年份：2020
Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown en...
[期刊论文] 作者：Dongdong Ti,Xin Yan,Jianshu Wei,Zhiqiang Wu,Yao Wang,Weidong Han,
来源：中国癌症研究（英文版） 年份：2022
Immunotherapy has revolutionized cancer treatment and substantially improved patient outcomes with respect to multiple types of tumors.However,most patients cannot benefit from such therapies,mainly due to the intrinsic low immunogenicity o......
[期刊论文] 作者：rg Teichmann,Shibani Bose,Weidong Han,Xiaoming Wang,
来源：城市道桥与防洪 年份：2018
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生、测量监控等方面人手,介绍了S226海滨大桥...
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing ad
[期刊论文] 作者：Kaichao Feng,Yelei Guo,Hanren Dai,Yao Wang,Xiang Li,Hejin Jia,Weidong Han,,
来源：Science China(Life Sciences) 年份：2016
The successes achieved by chimeric antigen receptor-modified T(CAR-T) cells in hematological malignancies raised the possibility of their use in non-small lung...
[期刊论文] 作者：Xiaolei Li,Hanren Dai,Xian Li,Ping Li,Wenbin Qian,Aibin Liang,Weidong Han,
来源：中国免疫学杂志（英文版） 年份：2022
Chimeric antigen receptor (CAR) T-cell therapy utilizes patients\' own T lymphocytes that are engineered to attack cancer cells[1-3].With the US Food and Drug Administration (FDA) approval of four CD19-and one BCMA-targeted CAR therapy for ......
Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological s
[期刊论文] 作者：Dongfang Liu,Shuo Tian,Kai Zhang,Wei Xiong,Ndongala Michel Lubaki,Zhiying Chen,Weidong Han,
来源：蛋白质与细胞 年份：2017
Cytotoxic T lymphocytes (CTLs) and natural killer (NK)cells contribute to the body’s immune defenses.Current chimeric antigen receptor (CAR)-modified T cell im...
[期刊论文] 作者：Dongdong Ti,Miaomiao Bai,Xiaolei Li,Jianshu Wei,Deyun Chen,Zhiqiang Wu,Yao Wang,Weidong Han,
来源：中国科学：生命科学（英文版） 年份：2021
Impaired tumor-specific effector T cells contribute to tumor progression and unfavorable clinical outcomes.As a compensatory T cell-dependent cancer immunoediti...
,Phase Ⅰ study of chimeric antigen receptor modified T cells in treating HER2-positive advanced bili
[期刊论文] 作者：Kaichao Feng,Yang Liu,Yelei Guo,Jingdan Qiu,Zhiqiang Wu,Hanren Dai,Qingming Yang,Yao Wang,Weidong Han,
来源：蛋白质与细胞 年份：2018
This phase Ⅰ clinical trial (NCT01935843) is to evaluate the safety,feasibility,and activity of chimeric antigen receptor-engineered T cell (CART) immunotherap...
,Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cel
[期刊论文] 作者：Yanjing Song,Chuan Tong,Yao Wang,Yunhe Gao,Hanren Dai,Yelei Guo,Xudong Zhao,Yi Wang,Zizheng Wang,Weidong Han,
来源：蛋白质与细胞 年份：2018
Human epidermal growth factor receptor 2 (HER2) proteins are overexpressed in a high proportion of gastric cancer (GC) cases and affect the maintenance of cance...
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of cli
[期刊论文] 作者：Zhang,Xiaoming Wei,Yukun Guan,Jiejie Liu,Kaichao Feng,Miao Jing,Xurui Wang,Yun-Cai Liu,Qian Mei,Weidong Han,
来源：细胞研究（英文版） 年份：2020
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to...
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