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Clinical Pharmacology Research in ChinaPast and Present--A story of an innovative target antitumor d
[会议论文] 作者:Pei Hu,
来源:第五届定量药理学与新药评价国际会议 年份:2015
Outline· Past-There was no guidance in those early years -Mainly conducted BE trials of generic drugs -Generic PK trials of imported drugs requested by SFDA ·...
Alternative Methods for CYP2D6 Phenotyping: Comparison of Dextromethorphan Metabolic Ratios from AUC
[会议论文] 作者:Rui Chen,Pei Hu,
来源:第十四届全国生化与分子药理学学术会议 年份:2015
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[会议论文] 作者:Dongyang Liu,Pei Hu,
来源:第五届定量药理学与新药评价国际会议 年份:2015
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Alternative Methods for CYP2D6 Phenotyping: Comparison of Dextromethorphan Metabolic Ratios from AUC
[会议论文] 作者:Rui Chen,Pei Hu,
来源:第十四届全国生化与分子药理学学术会议 年份:2015
Purpose:Cytochrome P450 2D6 (CYP2D6) is one of the most widely investigated polymor phic enzymes owing to its wide inter-individual and inter-ethnic variations.It is convenient to test genotypes clini...
Evaluation of the phenotyping methods of CYP2D6 using aphysiologically-based pharmacokinetic model o
[会议论文] 作者:Rui Chen,Pei Hu,
来源:第五届定量药理学与新药评价国际会议 年份:2015
Background and Aim: Hepatic enzyme CYP2D6 plays an important role in metabolizing many drugs and its genetic polymorphism results in significant individual therapeutic difference.Estimating the phenot...
Predictions about probabilities of adverse events and appropriate dose of roflumilast for Chinese CO
[会议论文] 作者:Xinge Cui,Xin Zheng,Pei Hu,Ji Jiang,
来源:第五届定量药理学与新药评价国际会议 年份:2015
...
Population pharmacokinetic pharmacodynamics model for PEGylated human growth hormone in healthy subj
[会议论文] 作者:Xin Zheng,Xia Chen,Pei Hu,Ji Jiang,
来源:第五届定量药理学与新药评价国际会议 年份:2015
...
Application of population pharmacokinetic modeling in clinical development of a novel PPI CPRCX: com
[会议论文] 作者:Xuemei Liu,Hongyun Wang,Pei Hu,Ji Jiang,
来源:第五届定量药理学与新药评价国际会议 年份:2015
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Application of population pharmacokinetic modeling in clinical development of a novel PPI CPRCX: com
[会议论文] 作者:Xuemei Liu,Hongyun Wang,Pei Hu,Ji Jiang,
来源:第五届定量药理学与新药评价国际会议 年份:2015
CPRCX is a novel investigated proton pump inhibitor, which shows dramatic success in the management of acid-related disorders.Now this drug is being developed in Phase Ⅱ study in China.In this paper f...
Population pharmacokinetic pharmacodynamics model for PEGylated human growth hormone in healthy subj
[会议论文] 作者:Xin Zheng,Xia Chen,Pei Hu,Ji Jiang,
来源:第五届定量药理学与新药评价国际会议 年份:2015
Background: Growth hormone deficiency (GHD) in paediatric and adult patients so currently necessitates long-term treatment and persistence with a daily s.c injection regimen.Taking the low compliance...
Predictions about probabilities of adverse events and appropriate dose of roflumilast for Chinese CO
[会议论文] 作者:Xinge Cui,Xin Zheng,Pei Hu,Ji Jiang,
来源:第五届定量药理学与新药评价国际会议 年份:2015
Backgrounds: Roflumilast is an oral inhibitor of phosphodiesterase 4(PDE4), which is mainly metabolized by CYP3A4 and CYP1A2.The main metabolite of it is roflumilast N-oxide, which contributes to the...
Effect of Target-Mediated Drug Disposition on CPRC3 Pharmacokinetics and Pharmacodynamics in Healthy
[会议论文] 作者:Zhenlei Wang,Qian Zhao,Dongyang Liu,Yupeng Ren,Ji Jiang,Pei Hu,
来源:第五届定量药理学与新药评价国际会议 年份:2015
Background: The prevalence of diabetes mellitus (DM) dramatically increased over the past decades.Dipeptidyl peptidase Ⅳ (DPP-4) inhibitors are a relatively new group of anti-diabetic agents.CPRC3 is...
[会议论文] 作者:Jun Shi,Sheng Feng,Meret Martin-Facklam,Cornelia Weber,Richard Peck,Neil Parrott,Pei Hu,Tomohisa Saito,
来源:第五届定量药理学与新药评价国际会议 年份:2015
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[会议论文] 作者:Sheng Feng,Jun Shi,Neil Parrott,Pei Hu,Cornelia Weber,Meret Martin-Facklam,Tomohisa Saito,Richard Peck,
来源:第五届定量药理学与新药评价国际会议 年份:2015
Background and objectives: Bitopertin (RG1678, RO4917838) is a glycine reuptake inhibitor that is postulated to improve NMDA receptor hypofunction by increasing the synaptic concentration of glycine,...
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