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HHT1843,a novel BET inhibitor,exhibits antitumor activity in a broad spectrum of cancer harboring di
[会议论文] 作者：Qimei Wu,Liming Zhang,Xin Xu,Yunfei Li,Jian Ge,Zhen Zhang,
来源：2019中国肿瘤学大会 年份：2019
Objective The Bromodomain and Extra-Terminal Domain(BET)family of proteins,including BRD2,BRD3,BRD4,and BRDT in mammalian cells,are epigenetic readers that bind to acetylated-lysine residues in histon...
The Triage Roles of High-Risk Human Papillomavirus 52 and 58 for HPV Primary Cervical Cancer Screeni
[会议论文] 作者：Ling Li,Longyu Li,
来源：2019中国肿瘤学大会 年份：2019
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A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breas
[会议论文] 作者：Li Li,Zhijie Liu,
来源：2019中国肿瘤学大会 年份：2019
Objective YAP/TEAD are nuclear effectors of the Hippo pathway regulating organ size and tumorigenesis through promoter-associated functions.However,their function as enhancer regulators remains poorly...
CDX2 inhibits Proliferation and Glucose Metabolism Reprogram by Targeting PGAM1 in Colorectal Cancer
[会议论文] 作者：QINGGUO LI,Qingguo Li,
来源：2019中国肿瘤学大会 年份：2019
Objective Cancer cells are characterized by increased glucose uptake,increased lactate production,and decreased respiration,even under aerobic conditions,which known historically as the Warburg effect...
PD-L1 competitively inhibits the binding of Cetuximab to EGFR,leading to the resistance of Cetuximab
[会议论文] 作者：Rui Ma,Xiujuan Qu,Xiaofang Che,Ling Xu,Ce Li,Yunpeng Liu,
来源：2019中国肿瘤学大会 年份：2019
Objective Cetuximab is monoclonal antibody directed against EGFR that inhibit its downstream signaling pathways.As the key target drug in the treatment of colorectal cancer,it has been studied that Ce...
Profiles and co-occurrence patterns of antibiotic resistome and bacterial taxa in the reclaimed wast
[会议论文] 作者：Bing Li,Guijuan Zhang,Yuntao Guan,Renxin Zhao,Jie Feng,Liping Ma,
来源：NCEC2019第十届全国环境化学大会 年份：2019
Currently,wastewater reclamation is increasing and its application has expanded worldwide.Nevertheless,little is known regarding the potential for wastewater reclamation to disseminate ARGs and the ef...
[会议论文] 作者：Xiaogang Li,Jiang Xiao,Chuanxin Ma,Mir Md Abdus Salam,Guangcai Chen,
来源：NCEC2019第十届全国环境化学大会 年份：2019
Bamboo biochar(BC)has been reported as soil amendment and metal passivator widely.However,little is known on its effect on phytoremediation of heavy metal in polluted soil using fast-growing trees....
[会议论文] 作者：wei Li,Huan chen Cheng,Sheng wei Liu,Lin Qiu,Jun Ma,
来源：2019中国肿瘤学大会 年份：2019
Objective The tyrosine kinase inhibitors could treat CML effectively,but it has no effect on patients with T315I mutation.In this study,we observed the effect of Quecetin(Qu)on proliferation and Wnt/β...
Evolution and Dosimetric Analysis of MRI-detected Brainstem Injury Following Intensity Modulated Rad
[会议论文] 作者：Xiaodan Huang,Yangchan Li,Foping Chen,Weihong Zheng,Jun Ma,Ying Sun,
来源：2019中国肿瘤学大会 年份：2019
...
Bioinformatics analysis of differentially expressed miRNArelated mRNAs and their prognostic value in
[会议论文] 作者：Xiaowu Zhong,Jingdong LI,Maoyong Fu,Tianwu Chen,Daiyuan Ma,Xiaolan Guo,
来源：2019中国肿瘤学大会 年份：2019
...
[会议论文] 作者：Zhenming Liu,Yibo Li,Jianxing Hu,Yanxing Wang,Jielong Zhou,Liangren Zhang,
来源：2019中国化学会第十五届全国计算(机)化学学术会议 年份：2019
The ultimate goal of drug design is to find novel compounds with desirable pharmacological properties....
[会议论文] 作者：Jiayang Zhang,Yangtian Yan,Rong Hu,Ting Li,Wen-Ju Bai,Yang Yang,
来源：中国化学会第八届天然产物全合成青年学术研讨会 年份：2019
...
[会议论文] 作者：Yibo Li,Jianxing Hu,Yanxing Wang,Jielong Zhou,Liangren Zhang,Zhenming Liu,
来源：2019中国化学会第十五届全国计算(机)化学学术会议 年份：2019
“Molecular scaffold” is one of the most important and widely used concept in medicinal chemistry....
[会议论文] 作者：Yanxing Wang,Jianxing Hu,Yibo Li,Hongwei Jin,Liangren Zhang,Zhenming Liu,
来源：2019中国化学会第十五届全国计算(机)化学学术会议 年份：2019
Many helpful theories that have been facilitating drug discovery are based on physical fields,for example,pharmacophore theory is based on chemical bonding and chemical bonding ultimately depends on t...
Exploring Activation Mechanism Induced by Glutamate for one Homodimer of Class C GPCRs via Molecular
[会议论文] 作者：Ting Lei,Fuhui Zhang,Nian Xu,Zhenxin Hu,Menglong Li,Xuemei Pu,
来源：2019中国化学会第十五届全国计算(机)化学学术会议 年份：2019
Metabotropic glutamate receptors of class C GPCRs exist as constitutive dimers,which play important roles in activating excitatory synapses of the central nerve system.However,due to lack of crystal s...
[会议论文] 作者：Sen Li,Jin'an Zhao,Yameng Mei,Bangpeng Yuan,Junshuai Zhang,Jiyong Hu,
来源：第十一届全国化学生物学学术会议 年份：2019
Mitochondria participate in multifarious cellular functions,especially in energy production and cell apoptosis....
[会议论文] 作者：Yue Cao,Qiao-Yan Jiang,Jie Wang,Li Hu,Yanfang Yu,Feng Chen,
来源：2019第二十次全国电化学大会 年份：2019
...
Tim-3 promotes epithelial-to-mesenchymal transition(EMT)and inhibits apoptosis of cervical cancer ce
[会议论文] 作者：Shishi Yu,Ou Sha,Qian Hu,Wanling Li,Bingqiang Zhang,Binglan Zhang,
来源：2019中国肿瘤学大会 年份：2019
...
Standing-type magnetically guided capsule endoscopy versus gastroscopy for gastric examination:a mul
[会议论文] 作者：Huasheng Lai,Xinke Wang,Aimin Li,Pinghong Zhou,Bing Hu,Side Liu,
来源：2019中国肿瘤学大会 年份：2019
...
[会议论文] 作者：Junxian Li,Luyang Liu,Ziwei Feng,Xin Wang,Yubei Huang,Hongji Dai,Liwen Zhang,Fangfang Song,Dezheng Wang,Pengyu Zhang,Baoshan Ma,Haixin Li,Hong Zheng,Fengju Song,Kexin Chen,
来源：2019中国肿瘤学大会 年份：2019
Objective To explore the association between the levels of tumor markers(CA15-3,CA125 and CEA)and breast cancer survival by molecular subtype in a Chinese population.Methods We conducted a cohort stud...
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