pointmutation相关论文
Changing Gly311 to an acidic amino acid in the MATE family protein DTX6 enhances Arabidopsis resista
In modern agriculture,frequent application of herbicides may induce the evolution of resistance in plants,but the mechan......
Identification of Campylobacter jejuni and determination of point mutations associated with macrolid
The aim of the study was to develop a multiplex real-time PCR method to identify Campylobacter jejuni containing mutatio......
The expression patterns of NLRC5 and key genes in STAT1 pathway post infection with Salmonella pullo
INTRODUCTION Numerous researches have analyzed the expression patterns of different tissues and cells in mammalian,which......
Objective: To genetic analysis the CYP21A2 of seven patients with congenital adrenal hyperplasia and their parents.Metho......
Efficient discrimination of three hotspot mutations associated with aminoglycoside antibiotics induc
Aim: The 961delT, C1494T and A1555G mutations in the mitochondrial 12S rRNA are the hotspot mutations associated with am......
STYK1 404 tyrosine residue mutation enhances STYK1 mediated PI3K signaling transductions and human b
STYK1(putative serine/threonine and tyrosine kinase)is a newly identified novel oncogene which belongs to the receptor p......
Single Point Mutation in Adeno-Associated Viral Vectors-DJ Capsid Leads to Improvement for Gene Deli
Background: Rational design of AAV capsids is a simple method for enhancing AAV transduction efficiency.AAV-DJ is a high......
A sensitive method based on solid phase PCR on oligonucleotide array was established to detect two point mutations 1896G......
Molecular simulation investigation on the interaction between barrier-to-autointegration factor dime
The interaction between barrier-to-autointegration factor dimer(BAF2)and LEM domain of emerin(EmLEM was studied by molec......
Difference in DNA sequences in SSU rDNA variable regions among pathogens isolated from different epi
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目的 探讨desmin基因exon6 A360P错义突变与克山病心肌损伤的关系及exon6 A360P错义突变是否是慢型及潜在型克山病损伤的易感基因.......
目的 探讨Ⅰ型人类免疫缺陷病毒(HIV-1)包膜糖蛋白120 V4区氨基酸位点发生突变对CCR5及CXCR4嗜性毒株感染靶细胞能力的影响.方法 ......
该文检测了1例先天性肾上腺皮质增生症(CAH)小儿及其父母CYP21A2基因突变,复习该病的临床特征、治疗监测及分子遗传机制。采用QIAG......
目的对一个α珠蛋白基因新突变复合α地中海贫血的家系进行基因分析和产前诊断。方法采集家系成员的外周血标本进行血红蛋白毛细管......
AIM: To explore the expression of heparanase mRNA and point mutation in hepatocellular carcinoma (HCC).METHODS: Reverse ......
目的 探讨胰腺癌细胞株中Hedgehog信号通路活化与K-ras基因突变的相关性.方法 采用实时定量PCR法检测人胰腺癌细胞株SW1990、PaTu8......
目的 分析阴离子型胰蛋白酶原(PRSS2)基因G191R突变在急性胰腺炎(AP)和慢性胰腺炎(CP)患者中的发生率,探讨PRSS2基因突变对胰腺炎......
目的检测晚期胰腺癌患者溶质载体家族1号(SLC29A1)基因1288位点单核苷酸多态性(SNP)的序列，探讨其与吉西他滨化疗不良反应及预后的......
目的 了解肺炎支原体(mycoplasma pneumoniae,MP)对大环内酯类抗生素的耐药情况及耐药机制.方法 对370份咽拭子标本进行MP分离培养......
目的 对非缺失型假性肥大型肌营养不良(Duchenne/Becker muscular dystrophy,DMD/BMD)患者及其家族成员进行基因诊断,以提供准确的......
目的 探讨RT-ARMS-qPCR(real time amplification refractory mutation system quantitativePCR)系统定量测定线粒体DNA(mitochond......
目的对10例MELAS型线粒体脑肌病患者进行线粒体DNA A3243G点突变的检测。方法 用PCR-限制性内切酶分析法(restriction analysis)，......
目的了解氯喹单用及与青蒿琥脂伍用治疗恶性疟前后,pfcrt和pfmdr1抗药性有关基因的点突变变化特征. 方法使用PCR-RFLP技术检测基因......
探讨了Ｐ５３基因点突变检测在乳腺癌预后判断中的意义。...
目的 分析原发性非小细胞肺癌（ＮＳＣＬＣ）中ｐ５３基因５～８外显子点突变发生及意义。方法 动用聚合酶链反应－单链构象多态性分析方法（ＰＣＲ－ＳＳＣＰ分析法）进行检测。结......
目的:探讨小细胞肺癌的发生、发展机理,提高临床早期对小细胞肺癌患者的诊断水平.方法:应用免疫组化和聚合酶链式反应-单链构象多......
目的了解在人脑星形细胞瘤中PTEN/MMAC基因第五、第八外显子的突变情况及其在肿瘤恶性进展中的作用.方法应用聚合酶链反应(PCR),银......
