MORPHINE相关论文
目的:探讨小窝蛋白(Cav-3)/细胞外信号调节激酶(ERK)信号通路在吗啡预处理减轻慢性心力衰竭大鼠心肌缺血再灌注损伤中的作用。方法......
Clinical Efficacy of Acupuncture on the Morphine-related Side Effects in Patients Undergoing Spinal-
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With the shifting role of placebos,there is a need to develop animal models of placebo analgesia and elucidate the mecha......
Aim: To determine whether testosterone is involved in morphine withdrawal syndrome (WS). Methods: In order to induce dep......
ParecoxibsodiumandLocalInfiltrationAnalgesiaforPostoperativePainManagementAfterTotalKnee
Purpose: Effective analgesia can substantially affect rehabilitation and ultimate outcome after total knee replacement.H......
Objective Purpose: Pancreatic cancer is currently one of the deadliest of the solid malignancies and pain is one of the ......
Down-regulation of miR-134 preservating of retina ganglion cell by morphine in an optic nerve crushe
PURPOSE The current study examined if morphine could improve retinal function and retinal ganglion cells(RGCs)integrity ......
The effects of morphine on the presynaptic glutamate release in the pyramidal neurons of the basolat
By sustained activation of opioid receptors, chronic opioids cause analgesic tolerance, physical dependence, and opioid ......
Chronic morphine treatment impaired hippocampal long-term potentiation and spatial memory via accumu
Chronic exposure to opiates impairs hippocampal long-term potentiation (LTP) and spatial memory, but the underlying mech......
Effects of morphine on acquisition and retrieval of memory have been proven in the avoidance paradigms.In present study,......
Chronic morphine treatment selectively regulates voltage-gated calcium channels in the rostral ventr
Voltage-gated calcium channels are important targets for the treatment of allodynia.The rostral ventrolateral medulla(RV......
mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reacti
Emerging evidence indicates that metabotropic glutamate receptor 5(mGluR5)critically modulates drug and drug related beh......
Conditioned place preference(CPP)is widely used to explore reinforcing effects of addictive drug treatments in experimen......
Region-specific role of DNA methylation in the consolidation and reconsolidation of appetitive memor
Objective Recent studies indicated epigenetic modification,especially DNA methylation,play an important role in the syna......
Context-and time-dependent neurobiological and behavioral sensitization induced by a single morphine
Background and Ain Druginduced sensitization in the mesocorticolimbic systems has been thought to play an important role......
Chaperone heat shock protein 70 modulators dual-regulate the development of behavioral sensitization
Aim: Our previous studies have revealed behavioral sensitization, closely relating to drug addiction, mediated by chaper......
Single and repeated morphine administrations differentially regulate expression of Nethylmaleimide-s
The present study investigated the potential effects of single and repeated morphine treatments on gene expression of N-......
The influence of insular cortex on motivational aversion associated with morphine withdrawal and the
Aim: Negative affective state is thought to be an important factor that triggers relapse.In this study, the role of insu......
Distinctive change in the sensitivity of VTA-NAc dopaminergic pathway to morphine during prolonged w
Objective Drug withdrawal has been believed to be associated with dysregulation of reward properties, especially the dec......
Drug addiction and abuse have now been extremely serious problems in our society.It has been reported that environmental......
Effect and mechanism of morphine on the inhibitory transmission of dopamine neurons in the rat ventr
Among the most powerful analgesics, morphine is widely used in clinic.However, they are potentially extremely addictive ......
Introduction: Pain has been the fifth vital sign in clinical care,and pain management is an important need in clinical q......
Although evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG)......
Relationships between agmatine anti-abstinence syndrom and its inhibition on down-regulation of hipp
Agmatine derived from arginine is recently considered as a neurotransmitter and/or neuromodulator that potentiates mor p......
GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our pr......
Attenuation of Central Morphine-induced Analgesia by Central Administration of Ghrelin Receptor Agon
GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our pr......
Background and Aim: Cholinergic system can affect the drug reward.We aimed to examine the roles of muscarinic acetylchol......
Essential role of NO signaling pathway in hippocampal CA1 in morphine-associated memory depends on g
OBJECTIVE The nitric oxide(NO)/soluble guanylyl cyclase(sGC)/cGMP-dependent protein kinase(PKG)signaling pathway has bee......
Opioid dependence and addiction,which is characterized by the loss of control over drug taking and drug seeking despite ......
Switching from Morphine to Fentanyl Attenuated the Decline of μ-Opioid Receptor Expression in Periaq
Opioid switching is a therapeutic maneuver as a method of improving analgesic response and/or reducing adverse side effe......
EXTINCTION OF AVERSIVE MEMORIES ASSOCIATED WITH MORPHINE WITHDRAWAL REQUIRES ERK-MEDIATED EPIGENETIC
Recent evidence suggests that histone deacetylase (HDAC) inhibitors facilitate extinction of rewarding memory of drug ta......
Chronic psychological stress in adolescence influenced novel object approaching behavior and morphin
One major consequence of early adversity is a markedly increased risk for substance use, abuse, and dependence.Long-term......
Efficacy of the combination of flurbiprofen axetil and opioids for patients with refractory cancer p
Context: Cancer pain is hard to be controlled and usually influences life quality of the patients.Diminishing pain and i......
Development and extinction of naloxone precipitated withdrawal-induced conditioned place aversion in
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Lesions of the nucleus accumbens prevent the expression but not induction of morphine-induced behavi
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Estrogen in the rostral ventromedial medulla potentiates visceral nocifensive responses via GPR30-me
A large body of experimental and clinical evidence suggests that estrogen may regulate pain, yet the exact role and the ......
Role of the NR2B-containing NMDA receptor-ERK pathway in nucleus accumbeus shell in morphine-associa
Learned associations between the rewarding effect of addictive drugs and drug-paired contexts resist extinction and cont......
Effects of physostigmine on the conditioned locomotion and the locomotor sensitization to morphine i
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Switching from morphine to fentanyl attenuates the decline of μ-opioid receptor expression in periaq
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Inhibition of the reinstatement of morphine-induced place preference in rats by high-frequency stimu
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Anti-apoptotic effect of morphine-induced delayed preconditioning on pulmonary artery endothelial ce
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Changes of dopamine transporter function in striatum during acute morphine addiction and its abstine
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慢性疼痛是晚期癌症患者常见的临床表现，疼痛治疗也是癌症治疗的一部分，中重度疼痛时即提倡开始使用阿片类药物进行滴定止痛，以期提高......
