SiRNAs相关论文
Gametocidal(Gc)chromosome can kill the gametes without themselves by causing chromosomal breakage to ensure their prefer......
RNAi-based therapy has emerged as a powerful strategy for treatment of various diseases including cancer1....
Experimental study on siRNA expressing vector-based RNA interference targeting c-Myc in human hepato
Objective: To explore the inhibition of the expression of c-Myc in human hepatocellular carcinoma via vector-based RNA i......
With the many changes that have taken place in people’ s diet and lifestyle, colorectal cancer (CRC) has become a globa......
In this review,we discuss recent advances in nucleic acid-based therapeutic technologies that target hepatitis C virus(H......
Prediction of VIGS efficiency by the Sfold program and its reliability analysis in Gossypium hirsutu
包括棉花(Gossypium hirsutum ) ，在某植物种类的基因转变被勤劳、费时间的过程并且经常妨碍难以实现。由双 stranded RNA 的导致病......
Synthesis,physicochemical and biological properties of oligonucleotides incorporated with amino-ison
Antisense oligonucleotides (ASON ) 和 siRNAs 为细胞、病毒的基因表示的规定广泛地被使用了，并且 RNAi 当前是为反肿瘤和抗病毒......
Synthesis,physicochemical and biological properties of oligonucleotides incorporated with amino-ison
Antisense oligonucleotides(ASONs) and siRNAs have been applied extensively for the regulation of cellular and viral gene......
A disulfde-modifed nucleoside was designed and synthesized. After loading the modifed nucleoside on controlled pore glas......
Interleukin-5 (IL-5) accompanies the development of airway inflammation and hyperresponsiveness through the activation o......
Effective suppression of fibronectin synthesis by retrovirus delivered shRNA in rat cardiac fibrobla
Extracellular matrix overexpression is a common final pathway that leads to ven-tricular remodeling. Fibronectin plays a......
RNA interference(RNAi)is an adaptive defense mechanism through which double-stranded RNAs silence cognate genes in a se......
目的肠道病毒71型(Enterovirus 71,EV 71)是手足口病(hand,foot and mouth disease,HFMD)主要的病原体之一。研究RNA干扰技术抑制......
以前的研究发现,细胞的Poly(C)结合蛋白2(PCBP2)可以下调水疱性口炎病毒的基因表达。作者的研究表明,水疱性口炎病毒感染可以诱导......
Background The B7/CD28 pathway provides critical costimulatory signals for complete T cell activation, and members of th......
AIM:To synthesize three small-interference RNAs (siRNAs)by T7 RNA polymerase-catalyzed reaction,and to investigatetheir......
肺癌是世界上最常见和最致命的恶性肿瘤之一。由于肺癌生物学特性复杂,恶性程度高,治疗效果不理想,使其成为危害人们生命健康的首......
Nano-sized quantum dots(QDs) exhibit uniquely optical properties that are tunable with different sizes and shapes.QDs ca......
Inhibitory effect of synthetic small interfering RNAs on glial fibrillary acidic expression in astro
BACKGROUND:Glial fibrillary acidic protein(GFAP) expression highly correlates with spinal glial scar formation,and is re......
AIM:RNA interference(RNAi)is a newly discoveredphenomenon provoked by dsRNA.The dsRNA is initiallycleaved by Dicer into......
Inhibition of beta-site amyloid precursor protein-cleaving enzyme and beta-amyloid precursor protein
BACKGROUND:Previous studies have demonstrated that Piper futokadsura stem selectively inhibits expression of amyloid pre......
PSD95 Gene Specific siRNAs Attenuate Neuropathic Pain through Modulating Neuron Sensibility and Post
Objective To observe the effects of PSD95 gene specific siRNAs on neuropathic pain relief, neuron viability, and postsyn......
Combination of small interfering RNAs mediates greater suppression on hepatitis B virus cccDNA in He
AIM: To observe the inhibition of hepatitis B virus (HBV) replication and expression in HepG2.2.15 cells by combination ......
To determine whether RNA interference (RNAi) could block cytotoxic T-lymphocyte antigen 4 (CTLA4) in human lymphocytes i......
AIM:To explore the role of high-mobility group box 1 (HMGB1) protein during liver fibrogenesis and investigate the funct......
RNA interference (RNAi) induces gene silencing at a level of posttranscription mediated by double stranded RNA. There ar......
早在1990年,人们就尝试利用反义链来抑制基因表达,并提出了核酸治疗的概念.RNA干扰(RNA interference,RNAi)是真核生物中普遍存在......
Inhibitory effect of vascular endothelial growth factors-targeted small interfering RNA on prolifera
AIM: To examine the effects of vascular endothelial growth factor (VEGF)-targeted small interfering RNA (siRNA) on proli......
RNA interference (RNAi) is a remarkable type of generegulation based on sequence-specific targeting anddegradation of R......
AIM: To investigate the biological features of A549 cells in which epidermal growth factor (EGF) receptors expression we......
AIM: To study the effect of short hairpin RNAs (shRNAs) expressed from DNA vector on hTERT expression. METHODS: Oligonuc......
Establishment of a Screening System for Selection of siRNA Target Sites Directed against Hepatitis B
To study the inhibitory effects of plasmid-derived small interfering RNA(siRNA)andsynthetic siRNA on the expression of ......
RNA interference (RNAi) is triggered by the presence of a double-stranded RNA (dsRNA), and results in the silencing of h......
Inhibition of vascular endothelial growth factor gene expression by T7-siRNAs in cultured human reti
Background Retinal pigment epithelial (RPE) cells play an important role in the occurrence of choroidal neovascularizati......
AIM: To study the inhibitory effects of siRNAs targeting different hTERT sequences and to screen the effective siRNA seq......
Specific anti-viral effects of RNA interference on replication and expression of hepatitis B virus i
Background RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Our previous st......
Cost-effective method of siRNA preparation and its application to inhibit hepatitis B virus replicat
AIM: To find a cost-effective method of preparation of short interfering RNAs based on cloning, fermentation, digestion ......
Reversal of the phenotype by K-ras~(val12) silencing mediated by adenovirus-delivered siRNA in human
AIM: To investigate the in vitro antitumor effect of adenovirus-mediated small interfering RNAs (siRNAs) on pancreatic c......
RNA干扰已经成为敲除特定基因表达的重要工具。将一段双链RNA序列导入机体或细胞中,使具有同源序列的基因表达受到抑制,由于这是一......
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play importan......
siRNA-mediated silencing of Cockayne Cyndrome group B gene potentiates radiation-induced apoptosis a
Background Cockayne syndrome (CS) is a rare human genetic disorder characterized by increased UV sensitivity, developmen......
Small interfering RNA-mediated inhibition of hepatitis G virus gene expression in human hepatoma cel
The RNA interference (RNAi) phenomenon is a recently observed process in which the introduction of a double-stranded, sm......
RNA INTERFERENCE OF ANNEXIN II GENE IN PC3 CELLS BY USING SMALL INTERFERENCE RNA SYNTHESIZED WITH IN
Objective To silence annexin II gene expression by using small interference RNA (siRNA) in prostate cancer cell line PC3......
RNA干扰(RNA interference,RNAi)是双链RNA介导的转录后基因沉默现象.在无脊椎动物中,直接给予长的双链RNA(double-strand RNA,dsR......
近来研究表明非编码的小RNAs在转录和转录后水平对基因表达具有重要调控作用。最近,在雄性生殖细胞中发现了一系列“与Piwi(P-elem......
Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed......
RNA干扰(RNA interference,RNA i)最早于上世纪90年代初在植物细胞中被发现,后来很快发现在其他生物中也存在这种现象,现已明确RNA......
