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EfficacyandTolerabilityofCrizotinibintheTreatmentofALKpositive,AdvancedNon-small-cellLun
目的 Crizotinibhasbeenreportedtobeparticularlyeffectiveandtohaveacceptabletoxicityinadvancedanaplasticlymphomakinase(ALK......
Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Qishe Pill in Healthy Chinese Subject
To assess pharmacokinetics, pharmacodynamics, tolerability and safety of oral medication of Qishe Pill, a compound tradi......
Systematic Review and Meta-analysis: Sodium Picosulfate/Magnesium Citrate vs.Polyethylene Glycol for
BACKGROUND & AIMS Previous studies comparing sodium picosulfate/magnesium citrate (SPMC) with polyethyl ene glycol (PEG)......
For the Chinese people, dose the dosage of administration need to adjust? A phase I study of PEG-rhG
Objective Chemotherapy-induced neutropenia (CIN) is one of the major toxicities in cancer patients subjected to chemothe......
Population Pharmacokinetic/Pharmacodynamics Modeling and Safety/Tolerability Assessing of Qishe Pill
Purpose:To assess pharmacokinetics,pharmacodynamics,tolerability and safety of oral medication of Qishe Pill in healthy ......
Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Qishe Pill in Healthy Chinese Subject
...
Background: Tenofovir disoproxil fumarate has been approved worldwide for the treatment of Chronic Hepatitis B in adults......
Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study to Evaluate the Safety, Tolerabili
Background: Benvitimod is a newly synthesized non-steroidal small molecule, which is aimed at the treatment of psoriasis......
Objective T0001 is the first mutant of etanercept known to exhibit a higher affinity to tumor necrosis factor α(TNF-α)......
(R,R)-penehyclidine fumarate in healthy subjects:a phase 1 randomized,double-blind,single-dose escal
Purpose:(R,R)-Penehyclidine fumarate(R2PHF)is a highly selective muscarinic receptor antagonist used as a preoperative g......
Tolerability and toxicity of adjuvant cisplatin and gemcitabine for treating non-small cell lung can
...
Safety, Tolerability and Pharmacokinetic Study of Recombinant Human Parathyroid Hormone [rhPTH (1-84
h. The parameters indicated the serum levels were directly proportional to the administered dose, with the mean Cmax and......
Pharmacokinetics and Tolerability of Oral Dosage Forms of Huperzine A in Healthy Chinese Male Volunt
Huperzine A is a potent,reversible,and blood-brain barrier permeable acetylcholinesterase irhibitor.The aim of this stud......
本文采用高效液相色谱-串联质谱法(HPLC-MS/MS)研究两种氨氯地平片在健康人体内的药动学及生物等效性.采用随机双周期交叉实验设计......
目的:观察卢比替康片在人体的安全性,确定卢比替康片口服给药对肿瘤患者的最大耐受剂量(MTD)及剂量限制性毒性(DLT),为Ⅱ期临床研......
目的:观察聚乙二醇胸腺素α1注射液在健康志愿者的安全性和耐受性。方法:单次给药剂量组的36名健康志愿者分别接受7个剂量组(0.16,......
目的:观察人体对单次给予冻干重组胰高血糖素样肽-1受体激动剂(rE-4)的安全性和耐受性,同时考察rE-4在健康人体中的药动学特征.方......
目的:评价健康志愿者同时口服磷酸瑞格列汀和缬沙坦的安全性和耐受性。方法:采用二阶段交叉试验设计,纳入18~45岁健康受试者16例,......
目的:评价国产布南色林治疗急性精神分裂症的疗效及安全性.方法:采用随机双盲多中心活性药对照研究方法.将298例18～ 65岁急性精神分......
Phase Ⅰ trial of icotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in Ch
Background The preclinical experiments and studies of congener drugs show icotinib, a new epidermal growth factor recept......
Tolerability and toxicity of adjuvant cisplatin and gemcitabine for treating non-small cell lung can
Background The combination of cisplatin and vinorelbine is an evidence-supported regimen for adjuvant chemotherapy for t......
目的：分析左乙拉西坦(LEV)单药或联合用药治疗婴儿癫的长程保留率。方法回顾性分析2006年7月至2007年6月应用LEV治疗的婴儿癫患儿的......
Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-
AIM: To compare the efficacy and tolerability of S-pantoprazole (20 mg once a day) versus racemic Pantoprazole (40 mg on......
Safety, Tolerability and Pharmacokinetic Study of Recombinant Human Parathyroid Hormone [rhPTH (1-84
h. The parameters indicated the serum levels were directly proportional to the administered dose, with the mean Cmax and......
Phase Ⅰ trial of icotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in Ch
Background The preclinical experiments and studies of congener drugs show icotinib, a new epidermal growth factor recept......
目的评价老年患者经鼻胃镜检查的耐受性和心肺功能的影响。方法 849例年龄≥60岁患者分为经鼻胃镜组（TN组）644例和经口胃镜组（TO组）205......
目的评价健康志愿者单次口服奥扎格雷钠口服溶液的安全性并探索最大耐受剂量。方法按GCP要求设计试验方案。单剂量耐受试验将24名......
目的：研究健康志愿者对戒毒中药正通宁颗粒冲剂的耐受性。方法：３０名２０￣４０ａ的健康受试者随机进入试验组和安慰剂组。试验组药物剂量从１５－１８０ｇ．ｄ＾－１按不同剂......
Prospective single-blinded single-center randomized controlled trial of Prep Kit-C and Moviprep:Does
BACKGROUND Colonoscopy remains the gold standard for detection of colonic disease.An optimal evaluation depends on adequ......
目的:在中国健康成年志愿者中,评估连续口服甲磺酸加替沙星片的耐受性.方法:根据GCP原则设计试验方案,选择10名18～40岁健康男性受试......
目的：对比观察度洛西汀与硫酸吗啡缓释片与单用硫酸吗啡治疗癌痛的疗效与安全性，为肿瘤疼痛管理提供参考。方法：180例中重度癌痛患者......
为探讨强微乳酸粪肠球菌对pH、胃液、肠液、胆盐耐受性,采用不同pH值、牛瘤胃液、人工胃液、人工肠液及胆盐处理,测定乳酸粪肠球菌......
实验采用盆栽砂培法,以日本园试通用配方为基础营养液,设置150 mg/kg、200 mg/kg、250 mg/kg和300 mg/kg4 个Zn浓度处理,以不施入Z......
综述了植物修复技术的研究进展,从减少植物对重金属的吸收、细胞壁的阻碍作用、植物的螯合作用、加速体内重金属的外排、体内重金......
目的探讨超细鼻胃镜在l临床应用中的安全性和耐受性。方法将1500例行胃镜检查的患者随机分成两组，分别为超细鼻胃镜组和标准胃镜检......
双歧杆菌是一种经典的益生菌,其对人体健康的促进作用已得到了广泛的研究证明,在功能食品及药品中具有巨大的应用价值。目前成功应......
There is compelling evidence to support the quality,cost effectiveness and safety profile of non-anesthesiologist-admini......
Is a split-dose regimen of 2 L polyethylene glycol plus ascorbic acid tolerable for colonoscopy in a
AIM To evaluate the effectiveness and tolerability of a split-dose 2L polyethylene glycol (PEG)/ascorbic acid(AA) regime......
目的 通过治疗银屑病５０例临床观察。探讨部分病例未能治愈与机体对蝮蛇抗栓酶产生耐受性原因分析。方法 用蝮蛇抗栓酶０．７５ＩＵ加入生理盐水......
目的 研究盐酸去甲乌药碱（防治心绞痛药）注射液在健康人体的耐受性。方法 健康志愿者32名，分A、B、c、D4组，按0．5，1．0，2．0，4．0μg·kg^-1&......
目的研究中国健康受试者单次口服盐酸川丁特罗片（平喘药）的耐受性、安全性和药代动力学。方法采用剂量递增试验设计，30名健康志愿者随......
目的 评价重组（酵母分泌型）人血清白蛋白-人粒细胞集落刺激因子（Ⅰ）融合蛋白在健康受试者的耐受性和安全性。方法 将26例健康受试者（男......
目的：评价不同人群对于上颌前牙修复体的宽度与同名牙不一致时的可接受度。方法拍摄个别正常者最大微笑照，使用Photoshop CS5软件对......
Safety, Tolerability and Pharmacokinetic Study of Recombinant Human Parathyroid Hormone [rhPTH （1-84
The current study was designed to determine the safety,tolerability and pharmacokinetic parameters of recombinant human ......
目的评价冠心病稳定性心绞痛患者口服麝香保心丸6个月的耐受性及安全性。方法采用随机非盲两组平行对照研究方法，将200例冠心痛患者......
AIM:To compare the quality and tolerance of esophag ogastroduodenoscopy(EGD)-assisted and conventional split-dose polyet......
目的观察伊贝沙坦治疗轻、中度原发性高血压病人的疗效及耐受性.方法用伊贝沙坦治疗186例轻、中度原发性高压病人12周.结果病人于......
The aim of this study was to assess the effects of Sangrovit®, a standardized preparation of Macleaya cordata extrac......
Experience of more than 3000 cycles of Brazilian women using the contraceptive vaginal ring (nuvarin
Objective: To evaluate the profile of the Brazilianvaginal ring user, reasons for choosing it, satisfaction, menstrual p......
The objective of this study was to assess the effects of Sangrovit?, a standardized preparation of Macleaya cordata extr......
