huntingtin相关论文
Flavonoid reduces mutant huntingtin cytotoxicity through activating degradation by ubiquitin-proteas
Huntingtons disease (HD) is a familial neurodegenerative disorder caused by an aberrant expansion of polyglutamine in th......
This study aimed to develop a cell culture model of Huntington disease and observe the effect of sodium butyrate on this......
Huntingtons disease (HD) is a well-characterized disorder that shares many common pathological features,such as age-de-p......
Huntingtons disease (HD) is a progressive neurodegenerative disorder of the central nervous system, which is caused ......
Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In ad......
Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been i......
亨廷顿病 (HD)是一种神经系统遗传病 ,疾病基因 -HD基因已被克隆 ,HD基因第一位外显子内含有CAG三核苷酸重复扩展序列 ,HD基因的 (......
Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strat
A review of recent animal models of Huntington’s disease showed many microRNAs had altered expression levels in the str......
Animal models of Huntington’s disease: implications in uncovering pathogenic mechanisms and developi
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion......
Huntington’s disease (HD) is caused by an expansion of the polyglutamine tract in the protein named huntingtin.The expa......
,Sequestration of Glyceraldehyde-3-phosphate Dehydrogenase to Aggregates Formed by Mutant Huntingtin
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported to interact with proteins containing the polyglutamin......
Huntington’s disease (HD) is caused by an expansion of polyglutamine tract in N-terminus of huntingtin (htt).The mutati......
Truncated N-terminal huntingtin fragment with expanded-polyglutamine (htt552-100Q)suppresses brain-d
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Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mut
OBJECTIVE To investigate the autophagic effect of the compounds from the Chinese medicinal herbs,Radix polygalae as a po......
<正>Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has be......
Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strat
A review of recent animal models of Huntington’s disease showed many microRNAs had altered expression levels in the str......
亨廷顿氏舞蹈病（Huntington’s Disease，HD）是人类中枢神经系统的一种遗传性疾病。该病以舞蹈样动作、进行性痴呆为主要临床特征。病......
目的：探讨胰岛素对细胞内突变亨廷顿蛋白（Huntingtin，htt）聚集物形成及其细胞毒性的影响。方法：利用脂质体转染法在培养的Hela细胞和HEK......
目的:探讨胞浆内非聚集型突变亨廷顿蛋白(huntingtin, Htt)对神经细胞分化的影响.方法:利用磷酸钙沉淀法在培养的小鼠成神经瘤细胞......
The chaperone-like huntingtin-interacting protein, HYPK, has unusual biophysical behavior like an intrinsically unstruct......
亨廷顿舞蹈病的病理特征是神经元内存在突变亨廷顿蛋白聚集体,自噬是清除突变亨廷顿蛋白的重要途径之一。深入研究自噬形成分子调......
