Aim: To investigate the stereoselective metabolism of phencynonate.Methods: Phencynonate enantiomers were isocratically ......

Objective To investigate the in vitro stereoselective metabolism of phencynonate as a novel anticholinergic chiral drug.......

Aim: To study the stereoselective metabolism of phencynonate isomers and their molecular docking with the mACh receptor.......

东莨菪碱是当前抗晕动病最强的单药,但有明显的不良反应.根据"抗胆碱药的中枢解胆碱能活性大小并不与其不良反应相平行"的假设,作......

采用电子轰击质谱（EI—MS）、电喷雾电离质谱（ESI—MS）两种技术分别对苯环壬酯结构和裂解途径进行了研究。采用ESI—MS获得m／z 358[M＋H]^＋......

１２名男性健康志愿者随机分为两组，交叉口服抗胆碱Ｉ类新药盐酸苯环壬酯片剂２ｍｇ、４ｍｇ和水剂４ｍｇ。采用ＧＣ－ＭＳ方法测定血浆中药物浓度，进行药代动力及片剂相......

东莨菪碱是当前抗晕动病最强的单药,但有明显的不良反应.根据"抗胆碱药的中枢解胆碱能活性大小并不与其不良反应相平行"的假设,作......

目的探讨苯环壬酯抗惊厥的作用是否与非胆碱能系统有关.方法大鼠sc梭曼180μg@kg-1,惊厥出现后不同时间(5,20及40min)ip不同剂量阿......