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Background:Stent placement is increasingly used for complex intracranial aneurysms.However,its safety and efficacy have not been sufficiently evaluated.Methods:We searched six databases,including Pubmed,Embase,SCI-expanded,the Cochrane Library,ISI Proceedings and ProQuest Dissertations & Theses for the relevant studies using multiple key words from December,1997 to February,2009.We identified thirty-three studies that reported data from a total of 1069 patients with 1121 intracranial aneurysms.Results:The overall initial complete occlusion rate was 52.5％(456/869,95％ CI:49.2％-55.8％).The overall complication rate was 14.3％(162/1130,95％ CI:12.3％-16.4％),of which 3.6％(38/1044,95％ CI:2.5％-4.8％)were permanent.Clinical follow-up showed a dependence rate of 8.4％(39/465,95％ CI:5.9％-10.9％).Angiographic follow-up showed an improvement rate of 24.3％(117/481,95％ CI:20.5％-28.2％)and a recurrence rate of 12.9％(62/481,95％ CI:9.9％-15.9％).Chi-squared tests were performed to compare the following subgroups:self-expandable vs balloon-expandable stents,unruptured vs acutely ruptured aneurysms,and with vs without premedication.Statistical significance was reached in eight tests.Conclusions:Intracranial stent is a safe and effective tool for embolizing complex intracranial aneurysms.Self-expandable stents are significantly easier and safer than balloon-expandable stents with respect to navigation and deployment through the tortuous cerebral vasculature.Patients with acutely ruptured aneurysms are more likely to be dependent,but not more likely to suffer more procedure-related complications.