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5. Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst

Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst

来源 :中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 | 被引量 : 0次 | 上传用户：gongwj123

【摘 要】

：

OBJECTIVE Cytochrome P450 (CYP) 3A accounts for nearly 30% of total CYP enzymes in human liver and participates in the metabolism of over 50% of clinical drugs.CYP3A also plays an important role in th

【作 者】

：

WANG Xin LU Jian SHAO Yan-jiao QIN Xuan LIU Dao-zhi CHEN Ang LI Da-li LIU Ming-yao 

【机 构】

：

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life S

【出 处】

：

中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛

【发表日期】

：

2016年11期

【关键词】

：

compensatory regulation CRISPR-Cas9 CYP3A drug metabolism gene editing rat 

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　　OBJECTIVE Cytochrome P450 (CYP) 3A accounts for nearly 30% of total CYP enzymes in human liver and participates in the metabolism of over 50% of clinical drugs.CYP3A also plays an important role in the chemical metabolism, toxicity, and carcinogenicity.

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