【摘 要】
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Objective:To study the polymorphisms of CYP1A1 and GSTM1 and the susceptibility of lung cancer in Mongolia of China.Methods:Allele-specific PCR and a multiplex PCR were employed to identify the genoty
【机 构】
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School of Pharmacy,Inner Mongolia Medical University,Hohhot 010059,P.R.China
【出 处】
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2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议
论文部分内容阅读
Objective:To study the polymorphisms of CYP1A1 and GSTM1 and the susceptibility of lung cancer in Mongolia of China.Methods:Allele-specific PCR and a multiplex PCR were employed to identify the genotypes of I462V of CYP1A1 and GSTM1 in a case-control study of 210 lung cancer patients with bronchoscopy diagnosis and 210 matched controls free of malignancy.Results:The frequencies of the variant CYP 1A1 (Val/Val) genotypes and GSTM1 (-)in lung cancer groups were higher than that in control groups (15.24％ vs 7.4％ and 56.67％ vs 40.95％).
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