【摘 要】
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Objective To explore the clinical and laboratory features of chronic myeloid leukemia (CML) with atypical e14a3 and e19a2 BCR-ABL fusion gene subtypes.Methods We retrospectively analyzed a cohort of C
【机 构】
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The First Affiliated Hospital of Soochow University,Jiangsu Institute of Hematology
【出 处】
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The 35th World Congress of the International Society of Hema
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Objective To explore the clinical and laboratory features of chronic myeloid leukemia (CML) with atypical e14a3 and e19a2 BCR-ABL fusion gene subtypes.Methods We retrospectively analyzed a cohort of CML patients with Ph chromosome positive confirmed by cytogenetic and FISH but classical fusion transcripts e13a3 (b2a2)、e14a2 (b3a2)and e1a2 negative confirmed by conventional realtime quantification RT-PCR (RQ-PCR).Further RQ-PCR was done with the forward primer and reverse primer designed to detect rare atypical BCR-ABL fusion genes including e14a3 and e19a2 fusion transcripts.
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