ROCK is involved in vasculogenic mimicry formation in hepatocellular carcinoma cell line

来源 :中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议 | 被引量 : 0次 | 上传用户:laoyu2030
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective: To confirm whether RhoA/ROCK is involved in regulating the formation of tumor cell vasculogenic mimicry (VM).
其他文献
目的:建立大鼠血浆中京尼平苷快速液相色谱-串联质谱(LC/MS/MS)检测方法.方法:以芍药苷为内标,血浆样品用甲醇沉淀蛋白法处理,色谱柱为Agilent ZORBAX Eclipse plus-C18(2.1×150mm,3.5μm)柱;流动相为甲醇-SmM乙酸铵(含5mM乙酸)(60∶40);采用电喷雾离子化(ESI)和正离子多离子反应监测(MRM)方式检测京尼平苷.
Objective: To filter the genes related to lung cancer by network pharmacology and to discuss the relationship with lung cancer-related genes and influence factors.
康普瑞丁磷酸二钠(简称CA4P)是combretastatin的磷酸二钠盐,是一种靶向抗实体癌的前体药物.CA4P可以选择性地破坏肿瘤相关血管,通过秋水仙碱结合位点和内皮细胞微管蛋白β亚单位结合,导致微管解聚、破坏内皮细胞骨架,从而降低血流,达到阻断血管、靶向治疗的目的.目的:在患有实体肿瘤的病人中进行不同剂量注射用CA4P人体药代动力学研究.
会议
To evaluate the role of the DNA methylation of the CpG island within the PON1 promoter on the clinical efficacy of the dual-antiplatelet therapy of aspirin and clopidogrel in patients with CAD after p
目的:降低基质效应,建立测定人血浆中苯烯莫德的液相色谱-串联质谱(LC-MS/MS)法.方法:以氟代苯烯莫德为内标,血浆样品用四硼酸钠碱化后,用甲基叔丁基醚(MEBE)萃取,离心后取上清液氮气吹干,残渣用流动相复溶后进行LC-MS/MS分析.色谱条件:采用Ultra C18(50 mm×2.1 mm,5.0 μm)色谱柱,以乙腈、0.2 mmol.L-1甲酸铵(HCOONH4)为流动相,流速为30
Objective: To investigate the molecular mechanism of the action of H 11 against HBV infection, and provide the rationale for the development of novel non-nucleoside anti-HBV drugs that target La prote
Aims: β-arrestins, including β-arrestin1 and β-arrestin2, are multifunctional adaptor proteins.Recently, some new roles of β-arrestins in regulating intracellular signaling networks have been discover
Objective: The aim of the present study was to investigate the effect of paeoniflorin (Pae) on the recombinant human interleukin-1β (rhIL-1β)-stimulated human peripheral blood lymphocytes (PBLC) in vi
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that is characterized by increased cardiovascular morbidity and mortality, independent of the traditional risk factors for cardiovascula
Aim: In the formation process of atherosclerosis, naringin has showed potential protective effects.However, the mechanism responsible for it remains unclear.The aim of this trial was to determine the