【摘 要】
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Background Bone mesenchymal stem cells (BMSCs) therapy has modest success in ischemic heart disease but has been limited by poor survival in diseased microenvironments.Cellular repressor of E1A-stimul
【机 构】
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Department of Cardiology, Institute of Cardiovascular Research of People's Liberation Army, Shenyan
【出 处】
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第17届中国南方国际心血管病学术会议
论文部分内容阅读
Background Bone mesenchymal stem cells (BMSCs) therapy has modest success in ischemic heart disease but has been limited by poor survival in diseased microenvironments.Cellular repressor of E1A-stimulated genes (CREG) can prevent BMSCs from apoptosis in vitro; however, the effects of CREG-modified BMSCs on ischemic heart disease and the related mechanism remain undefined.Therefore, we designed to study the cardioprotective effects of CREG overexpression in BMSCs (CREGBMSCs) after transplantation into infarcted heart of rats.
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