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Opioid receptors were involved in the cardioprotective benefits elicited by pre-or postconditioning1,2.Sufentanil is a selective μ opioid receptor agonist in clinical use that possesses a cardioprotective effect against ischemia-reperfusion injury(I/R).Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, an independent risk factor for the development of ischemic heart disease.