In this research work,we have reported the synthesis of pure nano hydroxyapatite(HA)by wet precipitation method(refluxing)in less than 15 minutes at 100 °C.The study involved examing the impression of refluxing time on particle size to increase the surface area simultaneously.The morphology and surface of Nano-HA was characterized using SEM and BET.FTIR and XRD were used to confirm the molecular structure and the composition of nano-HA prepared of different particle size,respectively.The bioactivity of this material was investigated in simulated body fluid(SBF).Results demonstrated the potential use of nano-HA for biomedical applications,in particular,osteo-conductivity,unmatched anti corrosive properties and good thermal stability.