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5. Inhibitory protection of nitric oxide to L-type calcium channel in rat cardiomyocytes

Inhibitory protection of nitric oxide to L-type calcium channel in rat cardiomyocytes

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：hbh0429

【摘 要】

：

Nitric oxide (NO) slightly inhibits the calcium current (ICa,L) of L-type calcium channel (LTCC).The enhanced ICa,L induced by isoproterenol (ISO) in cardiomyocytes was decreased in nNOS knockout mice

【作 者】

：

岳志杰 余志斌 徐彭涛 谢满江 常惠 

【机 构】

：

第四军医大学 第四军医大学,航空航天生理学教研室,陕西省西安市,710032

【出 处】

：

中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

：

2014年7期

【关键词】

：

simulated weightlessness cardiomyocyte L-type calcium channel S-nitrosylation 

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　　Nitric oxide (NO) slightly inhibits the calcium current (ICa,L) of L-type calcium channel (LTCC).The enhanced ICa,L induced by isoproterenol (ISO) in cardiomyocytes was decreased in nNOS knockout mice or 4-week of tail-suspended (SUS) rats.The underlying mechanism is not resolved now.

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