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Polymersomes are the polymeric analogues of liposomes.Their bilayer is composed of amphiphilic block copolymers,resulting in an increased membrane thickness.Polymersomes therefore have an improved stability and a larger hydrophobic reservoir when compared to liposomes,which makes them interesting devices for application in drug delivery.In this presentation three different approaches will be discussed in which the unique properties of polymersomes are utilised for the construction of biofunctional nanodevices.In the first part a polymersome system will be presented with a fluidic membrane composed of the block polymer polybutadiene-poly(ethylene glycol).The optimal size for biodistribution and in vivo circulation is determined,as well as opportunities to functionalise the capsules to afford efficient in vivo transcytosis across the blood-brain barrier.