The benzimidazole and indolyl acrylamide derivatives are reported as potent diacylglycerol acyltransferase(DGAT) inhibitors.In order to understand the factors responsible for potency as well as inhibi
Many researches show that miRNAs are involved in many vital biological processes, including cell development, cancer progression, and immune system, by binding to the 3untranslated regions of their ta
Analyzing miRNA targets in the context of PPIN provides important insights into how the dynamics of a biological system can be controlled efficiently.Strongylocentrotus nudus is an important commercia
Controlling the dynamics of DNA translocation is a central issue in the emerging nanopore-based DNA sequencing.In the context of transverse tunneling-current DNA sequencing, we perform atomistic molec
The discovery that single molecules can be pulled has enabled unprecedented access to measurements of the energy landscape associated with structural transitions within proteins.However, some conforma
Atomic force microscopy(AFM) has supplied a powerful approach for the bioimaging applications since it can work in physiological environment to keep the natural structures of bio-samples.In the commer
KIF1A/unc104 is the founding member of kinesin-3 family and transports synaptic vesicle precursors in neuronal axons.Previous studies have demonstrated that a single monomer of KIF1A/unc104 can move a
Single-walled carbon nanotube (SWNT) coated with amphiphilic molecules such as DNA has many potential applications in biological and medical sciences.The control dispersion and precipitation of SWNT i
V1-ATPase is a rotary molecular motor in which the mechanical rotation of the rotor DF subunits against the stator A3B3 ring is driven by the chemical energy of ATP hydrolysis.Recently, we verified th