【摘 要】
：
During the neuronal development,the tremendous but tightly regulated expansion of plasma membrane is required for neurite outgrowth and arborization.However
【机 构】
：
Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
During the neuronal development,the tremendous but tightly regulated expansion of plasma membrane is required for neurite outgrowth and arborization.However the underlying mechanism which regulates this process remains largely unknown.Here we report a role of Lgll,a mammal homolog of Lethal giant larvae which is involved in secretion pathway of yeast,in neural development.Lgl1 is highly expressed in the rat brain.A large fraction of Lgl1 was associated with membrane.We found that Lgl1 was critical for dendrite outgrowth and arborization,since overexpression of Lgl1 in cultured hippocampal neurons resulted in an increase of dendrite length and branches whereas down-regulation of Lgl1 decreased dendrite growth.
其他文献
上周,政策敏感期以及“双节”所带来的节前效应导致市场出现了震荡向下的走势,而基金平均仓位也出现了9周以来的首次下降,这也显示了目前基金对后市偏谨慎的态度,未来的投资
背景:战创伤防治研究一直是军事医学领域的核心内容,建立可重复的针对战创伤性感染、全身炎症反应综合征、休克、多器官衰竭动物模型及以该动物模型为基础的新型治疗手段具有
脑啡肽(ENK)是阿片肽家族的重要成员之一,在神经系统内发挥多种生理功能.ENK能神经元是脊髓背角内重要的抑制性中间神经元,在感觉信息传递和调控中具有重要作用.由于成熟
发育调节脑蛋白(developmentally regulation brain protein,Drebrin)是肌动蛋白丝(Actin filaments,F-actin)的主要调节蛋白,Dbn1是小鼠drebrin基因,目前只有Minghao Ji
Oligodendrocyte progenitor cells (OPCs,NG2 glia) are a major glial population in the developing as well as mature central nervous system (CNS).In addition t
隆化县三年婴儿死亡原因分析隆化县妇幼保健院薜秀丽对隆化县１９９０～１９９２年婴儿死亡情况进行调查。结果：三年活产儿数总计１５７６０人，死亡２０３人，总死亡率１２．８８％，呈逐年上升趋势。死因及顺位：先天畸形、吸入性肺
Enriched Environment (EE) is a well-established paradigm for naturally increasing neural activity in vivo.Studies have shown that rearing adult rodents in e
全县自使用麻疹疫苗后取得明显的预防效果,其发病逐年下降,1989年全年无病例发生,但1991年疫情明显回升。全县累计发病161例,发病率为15.78/10万。3、4月为高峰,占全年病例
TRPC6是隶属于TRP(transient receptor potential,瞬时感受器电位)家族TRPC亚家族的一种钙可通透性的非选择性阳离子通道.RT-PCR结果显示,该基因主要表达于脑,肺,肾等组
Objective To observe the effect ofBuyang Huanwu Decoction (BYHWD) on neuron protection.Methods SD rats were given BYHWD or distilled water via gastrogavage