2. 您的位置
3. 首页
4. 会议论文
5. Synthesis and Biological Evaluation of Diverse Naphthoquinone Derivatives as Antitumor Agents

Synthesis and Biological Evaluation of Diverse Naphthoquinone Derivatives as Antitumor Agents

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：yw101

【摘 要】

：

1,4-Naphthoquinones(1,4-NQs)are a class of aromatic motifs that are widely present among natural products and synthetic analogues.Numerous 1,4-NQs derivatives with substituent at C-2 and-3 positions h

【作 者】

：

Chi Zhang Meining Wang Ao Zhang 

【机 构】

：

Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Naphthoquinone functional transformation antitumor activity 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　1,4-Naphthoquinones(1,4-NQs)are a class of aromatic motifs that are widely present among natural products and synthetic analogues.Numerous 1,4-NQs derivatives with substituent at C-2 and-3 positions have been previously reported due to synthetic ease.

其他文献

Construction of Histone lysine-specific demethylase 1(LSD1)overexpression vector

Histone lysine-specific demethylase 1(LSD1)is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3,thereby mediating gene repression[1].

会议

LSD13*LFAG-pIRES-EGFP-LSD1MGC-803Co-IP

Synthesis of MOE Modified Dinucleoside Phosphorodithioate via an H-phosphonothioate

Chemical modification,consisting of phosphorodithioate(PS2)and 2-O-Methyl(2-OMe)MePS2 on one nucleotide that significantly enhances potency and resistance to degradation for various siRNAs.

会议

2'-O-MOE 3'-H-phosphonothioate nucleosidephosphonodithioateMOE PS2 d

富勒烯阿霉素衍生物的合成

富勒烯的独特笼形结构赋予它特殊的物化性质及生物效应，有研究表明富勒烯对肿瘤细胞的生长有抑制作用，且能提高阿霉素等抗癌药物的效力，降低副作用。

会议

富勒烯阿霉素合成

Design and synthesis of novel benzimidazole-pyrimidine containing chalcone moiety conjugates

Benzimidazole moiety is a structural isostere of naturally occurring nucleotides and it has been extensively utilized as a drug scaffold in the medicinal chemistry.

会议

chalconesbenzimidazolebenzimidazole-pyrimidine

G9a原核表达载体的构建及蛋白的表达纯化

目的：G9a(常染色质组蛋白赖氨酸N-甲基转移酶2,euchromatic histone-lysineN-methyltransferase 2,EHMT2)的C-端含有经典的SET(Su(var),Enhancer of zeste,Trithorax)结构域,且毗邻两个富含半胱氨酸的区域,结构类似已知的组蛋白甲基转移酶Suv39h1,与Suv39h1 相比G9a 甲基催化活性高10～20 倍

会议

G9a原核表达重组表达载体

LSD1 Inactivator Inhibit EMT of Gastric Cancer Cells

Histone lysine specific demethylase 1(LSD1)is the first identified histone demethylase,which can demethylate mono-and di-methylated histon3 lysine 4(H3K41/2)and histone 3 lysine 9(H3K9me1/2)when it is

会议

EMTTGF-β1LSD1inhibitor

人胃癌MGC803多西紫杉醇耐药细胞株的建立及其耐药机制的研究

目前，胃癌在我国乃至全球范围内仍然是最常见的恶性肿瘤之一，其每年的死亡人数在各类癌症中排第二位[1]。手术、化疗和放疗是治疗胃癌的三大主要手段。

会议

胃癌细胞多西紫杉醇耐药机制

8-Azapurines as new inhibitors of LSD1

Lysine specific demethylase 1(LSD1)selectively removes methyl groups from monoand dimethylated histone 3 lysine 4(H3K4),lead to gene silencing[1].

会议

8-azapurinescancerLSD1 inhibitorssynthesis

海参硫酸软骨素寡糖的合成

海参硫酸软骨素(sea cucumber chondroitin sulfate)最早由Vieira 和 Mour(a)o[1]小组于1988 年从Ludwigothurea grisea 海参体壁中分离得到。

会议

海参硫酸软骨素化学合成寡糖生物学研究

Synthesis and anti-influenza A virus activity of 6'-amino-6'-deoxy-glycoglycerolipids anal

Various glycoglycerolipids isolated from natural products display notable anti-tumor,anti-viral and anti-inflammatory bioactivities.

会议

aminoglycoglycerolipidscytopathic effects (CPE)anti-influenza A virus (IAV)sy