【摘 要】
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Background: Persistent organic pollutants (POPs) cause various diseases in both human and wildlife and have become a new global environmental problem.The to
【机 构】
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生命科学与生物工程学院,北京工业大学,北京100124
【出 处】
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第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
论文部分内容阅读
Background: Persistent organic pollutants (POPs) cause various diseases in both human and wildlife and have become a new global environmental problem.The toxic effects of POPs can be induced through their binding to specific proteins in the body.For instance, recent studies revealed that widespread POPs, dichlorodiphenyldichloroethylene (4,4-DDE) and polychlorinated biphenyls (PCBs), are antagonists of androgen receptor (AR);2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) reduces rapidly the activity of CK2 (casein kinase Ⅱ) both in vivo and in vitro.However, the inhibition mechanisms remain elusive.
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