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OBJECTIVE To examine effect of pH on physiochemical properties of trans-resveratrol self-nanoemulsifying drug delivery system (RES SNEDDS).METHODS RES SNEDDS was prepared via pseudo-ternary phase diagram and its pH was adjusted to 6.8, 5.8, and 4.8, respectively.The three SNEDDS were converted into nanoemulsions by being exposed to 10 fold water, and zeta potential as well as size were measured.