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  5. Multifunctional thermo-sensitive liposomes for tumor-triggered targeting drug delivery

Multifunctional thermo-sensitive liposomes for tumor-triggered targeting drug delivery

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：wgl_future
【摘 要】
：
The ammonium bicarbonate (ABC) liposomes have shown to release doxorubicin (DOX) rapidly at elevated temperatures (40-42 ℃) and improve the intravenous stability at physiological temperature (37 ℃)[1]
【作 者】
：
Min Dai Yang Cheng Xiaoyan He Yu Zhou Tao Zou Jiabao Yah Danlin Zeng 
【机 构】
：
Key Laboratory of Coal Conversion & New Carbon Materials of Hubei Province,College of Chemical Engin
【出 处】
：
Fourth Symposium on Innovative Polymers for Controlled Deliv
【发表日期】
：
2016年11期
【关键词】
：
tumor-triggered targeting thermo-sensitive liposome drug delivery 
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　　The ammonium bicarbonate (ABC) liposomes have shown to release doxorubicin (DOX) rapidly at elevated temperatures (40-42 ℃) and improve the intravenous stability at physiological temperature (37 ℃)[1].However,the ABC liposomes are unable to enter the tumor cells because of containing PEG-lipids (DSPE-PEG2000).Therefore,drug release from ABC liposomes can be triggered only extracellularly.As is well-known,intracellular drug release is more promising than extracellular release in chemotherapy[2].
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