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Objective To explore the mechanisms of the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood.Methods The study participants were 11 primarily untreated multilple myeloma(median age: 58 years,range: 49 – 76 years)and 10 extramedullary plasmacytoma patients(median age: 64.5 years,range: 44-75 years).