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目的 总结我院近 9年来初发急性非淋巴细胞白血病 (ANL L )的治疗方案、疗效及影响因素。方法 对我院 1992～ 2 0 0 1年 391例 ANL L住院患者进行了回顾性总结和分析。结果 ANL L住院患者以 M2 最多 ,占33.2 %。 ANL L一疗程完全缓解率 (CR)为 5 3.7%。缓解率以 M3 最高 ,占 87.3%。老年人和高白细胞患者缓解率较低 ,分别为 2 5 .6 %和 37.5 %。诱导缓解方案与 CR率有关 ,维甲酸对 M3 的疗效最高 ,其他化疗方案对 CR率无明显差异。结论 一疗程治疗后 ,ANL L中 M3 缓解率较高。年龄大与白细胞高是影响一疗程 CR率的因素。化疗相关死亡主要原因为出血和感染
Objective To summarize the treatment, efficacy and influencing factors of acute non-lymphocytic leukemia (ANL L) in our hospital in the past 9 years. Methods 391 cases of ANL L hospitalized in our hospital from 1992 to 2001 were retrospectively summarized and analyzed. Results Most patients in ANL L hospitalized with M2, accounting for 33.2%. A course of complete remission (CR) of ANL L was 53.7%. Mitigation rate to M3 highest, accounting for 87.3%. The response rate of the elderly and high white blood cells was low, which was 25.6% and 37.5% respectively. Induction remission program and CR rate, the highest efficacy of retinoic acid on the M3, the other chemotherapy regimen no significant difference in CR rate. Conclusions After a course of treatment, the response rate of M3 in ANL L is higher. Age and high white blood cell factor is a CR rate of a course of treatment. The main cause of chemotherapy-related deaths is bleeding and infection