【摘 要】
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Objective: EGFR mutation is a strong predictor of EGFR-TKIs (epidermal growth factor receptor tyrosine kinase inhibitor) therapy in advanced NSCLC.Although as many as 20-30％ of EGFR-mutant cases EGFR
【机 构】
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Department of Thoracic Medical Oncology, Peking University School of Oncology, Beijing Cancer Hospit
【出 处】
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第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
论文部分内容阅读
Objective: EGFR mutation is a strong predictor of EGFR-TKIs (epidermal growth factor receptor tyrosine kinase inhibitor) therapy in advanced NSCLC.Although as many as 20-30％ of EGFR-mutant cases EGFR wild-type cases showed no response to EGFR-TKIs, suggesting that other determinants of outcome beyond EGFR mutation might exist.MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and small RNAs that regulate cell growth, apoptosis, signal transduction and drug resistance.
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