Novel pH-and amylase-responsive microgels for oral insulin delivery

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户:eline77
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  A series of pH-and amylase-responsive microgels were successfully prepared via dispersion polymerization of carboxymethyl starch-graft-acrylic acid (CMS-g-AA) and 2-(isobutyl)-acrylic acid (iBAA) in absence of surfactant for oral protein delivery (Fig.l).
其他文献
Compared with intravenous route,oral administration of drugs offers patients less pain,greater convenience,higher likelihood of compliance,and reduced risks of cross-infection and needle-related injur
Photodynamic therapy (PDT),has been widely concerned in recent years for cancer therapy.Among the existing NIR dyes,BODIPY dyes show high singlet oxygen quantum yield via heavy atom effect modificatio
Degradable polymers are potential for vaginal drug delivery.The drug could be loaded in environmentally sensitive gels,and be delivered into body without need of surgical procedure.In our previous wor
In the past few years,considerable interest has been devoted towards the design of new drug delivery systems,with excellent control over the structure and release profiles,among which,micromotors are
Intracellular production and excessive accumulation of reactive oxygen species (ROS) is deeply involved in inflammatory responses and disruption of metabolic activities,which would disturb the balance
Chemo-photodynamic therapeutics can function synergistically[1].Moreover,photodynamic therapy could be enhanced by a sequential release protocol[2].In our study,the sequential release of photosensitiz
Gels possessed tremendous potential promises for addressing the challenges in current drug delivery status[1].The inherent three-dimension network in gel could be regarded as an ideal candidate as dru
Synthetic polypeptides,which are biocompatible and biodegradable,have been extensively investigated for various biomedical applications,such as drug and gene delivery[1].As a typical example,phenylbor
Type Ⅰ diabetic patients are susceptible to osteoporosis,easily leading to bone defects and finally delayed fracture healing[1].Therefore,more targeted therapies are needed when treating this bone def
Mesoporous silica nanoparticles (MSN) have been intensively studied for drug delivery owing to their outstanding physicochemical properties.Specifically,the rational design of targeted and intelligent