Cardiovascular diseases (CVDs) are the leading causes of death and disability in the world.CVDs have emerged as a major health threat in developing countries contrary to the prior belief that they were confined primarily to industrialized nations.An estimated 17.3 million people died from CVDs in 2011 and over 80% of CVD deaths take place in low and middle-income countries.By 2030, almost 23.6 million people will die from CVDs.Therefore, finding ways to reduce the mortality of cardiovascular disease remains an important public health goal.Traditional Medicines have been an integral part of the healthcare system since time immemorial.WHO reports indicate that around eighty percent of the global population still relies on botanical drugs and several herbal medicines have advanced to clinical use in modem times.Unani occupies an important place in the rich traditional heritage of indigenous systems of medicine in India and contributes significantly to the health care.The core of treatment in Unani System of Medicine is based on drugs of herbal, mineral and animal origin.The ancient classical literature of Unani has mention of numerous drugs possessing cardioprotective and cardiotonic activity as well as catering to various aspects of CVDs.The Unani physicians have been using such drugs successfully since ages and this is possible only by inherent quality and safety standards specified in the system.With the advent of new techniques and recent upsurge towards scientific exploration of traditional medicines, empirical data substantiating their safety and efficacy has been generated and had lead to better understanding of their role to prevent and cure diseases.The aim of paper is to review and highlight the work done on some Unani single and compound cardioprotectives and cardiotonics as well as highlight the scientific exploration of the same.