【摘 要】
：
目的：抑癌基因启动子区高甲基化在乳腺癌的早期筛查和辅助诊断中具有很大价值,但在众多被发现甲基化的抑癌基因中作为用于乳腺癌筛查价值较大的甲基化基因尚不清楚.本研究利用间接比较的方法评价在乳腺癌中众多甲基化的基因的价值较大的基因.计算机检索The Cochrane Library、PubMed、EMbase、Chinese BioMedical Literature Databas.方法：e(CBM)
【机 构】
：
100069,北京市首都医科大学临床流行病学北京市重点实验室
【出 处】
：
首都医科大学公共卫生学院第六届研究生学术论坛
论文部分内容阅读
目的：抑癌基因启动子区高甲基化在乳腺癌的早期筛查和辅助诊断中具有很大价值,但在众多被发现甲基化的抑癌基因中作为用于乳腺癌筛查价值较大的甲基化基因尚不清楚.本研究利用间接比较的方法评价在乳腺癌中众多甲基化的基因的价值较大的基因.计算机检索The Cochrane Library、PubMed、EMbase、Chinese BioMedical Literature Databas.
方法：e(CBM)、Web of Science、中国知网(China National Knowledge Infrastructure,CNKI)和万方数据库,收集涉及抑癌基因启动子甲基化与乳腺癌关系的meta研究.采用间接比较meta分析的方法评价在乳腺癌患者中甲基化的抑癌基因的诊断价值.
结果：最终共纳入10个甲基化基因(10个meta研究),共计130个原始研究.在汇总的meta分析中,甲基化的同源性磷酸酶-张力蛋白基因(phosphatase and tensin homolog,PTEN)(比值比(odds ratio,OR)=66.16(24.48-178.82))、人类相关转录因子基因(Runt-related transcription factor3,RUNX3)(OR=28.88(15.48-54.25))对乳腺癌的风险最大,虽然乳腺癌1号基因(breast cancer1,BRCA1)(OR=2.11(1.88-2.35))最小,但是在10个meta研究中BRCA1的权重是57.1％.根据灵敏度相比之下,RUNX3基因(0.62(0.56-0.67))最大,其次是脆性组氨酸三联体基因(fragile histidine triad protein,FHIT)(0.59(0.54-0.63)),但是RUNX3基因的特异度(0.95(0.91-0、97))大于FHIT基因(0.65(0.61-0.69)).综合甲基化基因的灵敏度和特异度,利用间接比较的方法,RUNX3基因对乳腺癌的诊断价值最大..
结论：RUNX3甲基化基因相比于其他甲基化基因对乳腺癌的诊断价值更大,在乳腺癌的早期筛查和辅助检查中,提倡对RUNX3和BRCA1甲基化的基因加以利用.
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