高效液相色谱法快速测定吉米沙星尿药浓度及吉米沙星尿排泄研究

来源 :2015广东省药师周大会 | 被引量 : 0次 | 上传用户：lynxmao

【摘要】

：

目的：建立高效液相色谱法快速测定人尿液中吉米沙星药物浓度,并考察吉米沙星尿排泄情况.方法：色谱柱为Kromasil C18(5μm,250 mm×4.6 mm)；流动相为乙腈-10 mmol/L 醋酸铵缓冲液(pH2.2,含10mmol/L 高氯酸)(22：78,v/v)；柱温40℃；流速1.5 mL/min；检测波长为338nm.结果：本测定方法的线性范围：0.1～100 μg/mL,r=0.9

【作者】

：

何秋毅任斌元刚叶毅芳洪晓丹陈杰傅晓华

【机构】

：

中山大学附属第一医院,广东广州,510080 广州新海医院,广东广州,510300

【出处】

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2015广东省药师周大会

【发表日期】

：

2014年6期

【关键词】

：

吉米沙星尿药浓度高效液相色谱法

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高效液相色谱法快速测定吉米沙星尿药浓度及吉米沙星尿排泄研究

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