肿瘤细胞由于其自身的快速增殖、应对氧化应激和对生物大分子的需求会改变其自身代谢。转录因子阴阳1(YY1)在多种肿瘤中呈高表达，并且对肿瘤细胞增殖和转移发挥重要作用。然而，它在肿瘤细胞代谢重编程中是否起到调控作用尚未有报道。
PAQR9 is a member of the PAQR(progestin and adipoQ receptor)family,however,the investigation of obesity by PAQR9 has not been known.PAQR9 knockout(KO)mice are resistant to high fat diet(HFD)-induced o
OBJECTIVE: To investigate the effects of human umbilical cord mesenchymal stem cells(huMSCs)on the expression of IL-1β,IL-6,TNF-α and IFN-β in lipopolysaccharide(LPS)-induced macrophage inflammation b
Glucotoxicity and lipotoxicity are the key characteristics of type 2 diabetes mellitus(T2DM)in early stage.Recent reports demonstrated that patients of T2DM suffered from abnormal high levels not only
Magnesium(Mg)is the second abundant intracellular cation and the fourth abundant elements in the body.As it plays a complex function in our body,Mg,which accounts for only 0.05%of body weight and rega
Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS
蓝细菌光合系统通过铁氧还蛋白：NADP氧化还原酶(FNR)将还原力特异性地传递给NADP,产生NADPH用于推动CO2固定和其他生命过程。蓝细菌胞内的高NADPH/NADH比率限制了外源代谢途径在蓝细菌中的应用。改变FNR的辅因子特异性,使光合系统还原力合理分配,调整NADPH/NADH比率,将有助于提高光合作用效率和设计先进的光自养生物系统生产生物燃料分子和化学品。我们开发了一种偶联NAD(P)
神经管畸形(Neural tube defects,NTDs)是出生缺陷中发病率和死亡率最高的疾病,通常在0.6‰以下.中国是个人口大国,NTDs患者人群庞大,尤以山西省发生率最高,发生率已高达3.15‰,甚至个别地区已达到20‰,严重影响人口质量,也给社会医疗带来沉重压力.叶酸代谢障碍与NTDs以及神经系统严重畸形有关已被报道,叶酸通过甲基四氢叶酸,为S-腺苷蛋氨酸代谢提供甲基(SAM),SAM
MiR-181 family plays an important role in the regulation of various cellular functions.However,whether MiR-181b-5p mediates hepatic insulin resistance remains unknown.In this study,we found that miR-1
Extensive researches have suggested that miR-7 plays a critical role in cancer progression.However,the biological function of miR-7 in the pancreatic cancer(PC)progression is poorly understood.Therefo