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Fifteen new compounds,including nine polyoxygenated eremophilane sesquiterpenes periconianone C-K (1-9),four polyketide-terpenoid hybrid molecules periconones B-E (10-13),and two polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) hybrid metabolites periconiasins I (14) and J (15),were isolated from the endophytic fungus Periconga sp.