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Programmed Cell Death 4 (PDCD4) is a novel tumor suppressor, whose expression is frequently down-regulated in several types of cancers.Over-expression of PDCD4 has been demonstrated to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation and tumor phenotype.Ectopic expression ofpdcd4 cDNA in invasive colon RKO cells inhibits invasive capacity and AP-1 dependent transcription, and tumor cell intravasation.PDCD4 suppresses colon tumor cell invasion by inhibiting AP-1 dependent transcription through JNK signaling pathway.