TCF7L2 involvement in estradiol-and progesterone-modulated islet and hepatic glucose homeostasis

来源 :中华医学会第十四次全国内分泌学学术会议 | 被引量 : 0次 | 上传用户:subae
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Aims/hypothesis Estradiol (E2) and progesterone (P</span>4) have been reported to modulate glucose metabolism during pregnancy.In this study, we aimed to evaluate the role of TCF7L2, a key regulator of glucose homeostasis, in E2-and P4-modulated glucose metabolism.Methods Mouse insulinoma cells (MIN6) and human liver cancer cells (hepG2 and HUH7) were treated with physiological concentrations of E2 (100 nM) or P4 (1 μM) in the presence and absence of TCF7L2.Insulin/proinsulin secretion was examined in MIN6 cells, while glucose uptake and production were evaluated in liver cancer cells.
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