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The objective of this study is to develop a simple and useful method for fabricating three-dimensional scaffolds with desirable drug delivering property.Previously,Nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite porous scaffolds(group1) were used as the matrix and coated with homogenously chitosan layer(group2),vanillin((4-hydroxy-3-methoxybenzaldehyde) a popular flavour extracts broadly used in food)is chosen to crosslink the chitosan layer(group3) (Fig1(A)).