Decreased 5-methylated cytosine(5-mC)content of genome was induced in dopaminergic neurons in the su

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：robitewx

【摘要】

：

【作者】

：

Yan-Yan Wang Jian Yang Yong Wang Jun Jia Ke Wang Yan Yu Xiao-Min Wang

【机构】

：

Department of Neurobiology,Capital Medical University;Key laboratory ofNeurodegenerative Disorders o

【出处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

Parkinson's disease neurotoxicity genome 5-methylated cytosine

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　　Parkinsons disease(PD)is a progressive neurodegenerative disease related to aging,and is due to the degeneration and death of dopaminergic neurons in the substantia nigra pars compacta(SNc)of the ventral midbrain.DNA methylation,as one of typical epigenetic modifications,plays important roles in gene regulation.

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