【摘 要】
：
Autophagy (self-eating) is a catabolic process that targets cytoplasmic components for degradation by the lysosome.Autophagy is an important cellular response t
【机 构】
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Dept.ofCancerBiology,UniversityofMassachusettsMedicalSchool,USA
【出 处】
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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
Autophagy (self-eating) is a catabolic process that targets cytoplasmic components for degradation by the lysosome.Autophagy is an important cellular response to stress, and plays essential roles in development, aging, immunity, neurodegeneration and cancer.Studies of yeast led to the identification of conserved factors that regulate autophagy, but differences in the role of autophagy in distinct cell contexts suggest that specific regulators of autophagy may exist in multi-cellular organisms.We recently identified an Atg7-and Atg3-independent autophagy program that is required for cell size reduction and clearance of mitochondria in dying larval intestine cells during Drosophila development.This autophagy requires Uba1, the E1 for ubiquitination, and ubiquitin, as well as several other Atg genes.We have used this system to screen for new factors regulate cell size reduction, autophagy and clearance of mitochondria, and will present the identification and characterization of a novel gene that is required for autophagy.
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