A novel polyethyleneimine derivative for tumor-targeted gene delivery

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：yingzi9252

【摘要】

：

【作者】

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Xuefang Ding Wei Wang Jianping Zhou

【机构】

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State Key Laboratory of Natural Medicines,Department of Pharmaceutics,China Pharmaceutical Universit

【出处】

：

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

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2012年10期

【关键词】

：

Polyethyleneimine PDNA Transfection Targeted gene delivery

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　　The study aimed to develop a polyethyleneimine (PEI) derivative (ESP) with ES for gene delivery to improve the transfection efficiency and tumor targeting of PEI as a gene vector.The ESP was synthesized by a michael addition reaction between double bond of ES and PEI.The ESP/pDNA complexes were prepared,and their characterizations were investigated.The size of complexes was about 150 nm at optimal charge ratio.

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A novel polyethyleneimine derivative for tumor-targeted gene delivery

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