【摘 要】
：
Aim: Platinum-based chemotherapy is the main treatment method in lung cancer patients.The genetic polymorphism of Wnt inducible signaling pathway protein l(WISP1)was reported to be associated with the
【机 构】
：
Institute of Clinical Pharmacology, Central South University,Hunan Key Laboratory of Pharmacogenetic
【出 处】
：
中国药理学会生化与分子药理专业委员会2014年研讨会
论文部分内容阅读
Aim: Platinum-based chemotherapy is the main treatment method in lung cancer patients.The genetic polymorphism of Wnt inducible signaling pathway protein l(WISP1)was reported to be associated with the development of some lung diseases such as asthma and ventilator-induced lung injury.In this study, we aimed to investigate the relationship between WISP1 genetic polymorphisms and lung cancer susceptibility and platinum-based chemotherapy response in Chinese lung cancer patients.Methods: 556lung cancer patients and 254 health controls were enrolled in this study.The 28 SNPs of WISP1 gene were genotyped by SequenomMassARRAY.Result: We found that WISPlrs16893344, rs2977530,rs2977537, and rs62514004 polymorphisms were related to susceptibility of lung cancer;and WISP1rs16893344, rs11778573, and rs2977536 polymorphisms were significantly associated with platinum-based chemotherapy response in lung cancer patients.
其他文献
Aim: Licorice is used throughout the world as a traditional herbal remedy.According to Chinese traditional medicine licorice alone can be used to treat inflammation.Although there have been some studi
药物发育毒性是药物安全性评价的重要内容之一,指药物因素引起的子代从宫内到性成熟前出现的结构或功能损害,包括结构畸形、功能障碍、生长迟缓甚至死亡.目前国际上有关药物发育毒性研究主要集中在其近期毒性(如致畸、死亡),对于其远期效应及发生机制报道甚少.宫内生长迟缓(IUGR)不仅增加围产期死亡率,也可引起成年多种慢性疾病(如代谢性疾病)的易感性增加.咖啡因是IUGR发生的明确诱因.我们前期证实,孕期咖啡
国内约有1.2％的人群患有智力发育迟滞症.这类疾病主要是由遗传基因缺陷而引起的.、目前对智力发育迟滞症的治疗手段十分有限,这是对提高人们健康生活的一个挑战.如果能找到这二疾病的发病病因,了解其发病的机理,并进行早期治疗,有望减轻这一病症,减小社会对其护理的压力.近年来发现一个引起智力发育迟滞基因CRBN的突变,该突变在第419位氨基酸引入了一个终止密码子,从而导致其所表达的蛋白质失去了羧基端的24
The APJ is a class A, G protein coupled receptors, which coupled with its endogenous ligand apelin is vitally important for human.APJ is shown to be widely expressed in humans, with high levels in the
老年性痴呆人口数量的急剧增加已成为全球关注的焦点.大脑低灌注(cerebral hypoperfusion,CBH)被认为是诱发散发性AD和VaD的共同因素.痴呆主要的病理特征包括神经细胞外Aβ沉积及Tau蛋白磷酸化.前期的研究发现:2VO(bilateral common carotid arteries occlusion)大鼠表现为学习记忆功能的下降,miR-195通过调控APP、BACE1
As Alzheimer disease(AD) research moves to intervene in presymptomatic phases of the disease, we must develop outcome measures sensitive to the earliest disease related changes.A preclinical stage of
阿尔茨海默病(ALzheimers disease,AD)是引起老年人痴呆最主要的原因.AD特征性的病理改变包括细胞外由β-淀粉样蛋白(β-amyloid,Aβ)沉积形成的老年斑和细胞内以过磷酸化的Tau蛋白为核心形成的神经元纤维缠结,以及神经元和突触丢失.2-(旷羟基戊基)苯甲酸钾盐(Potassium 2-(1-hydroxypentyl)-benzoate,dl-PHPB)是中国医学科学院药
类风湿关节炎(RA)是一种慢性和系统性疾病,以自身免疫和炎症失调为特征.关节肿胀和骨损害为RA的两个主要症状,两者均由三个关键的炎症因子介导:TNFα、ILlβ和IL-6.已有研究通过小系统药理学(Small Systems Pharmacology)数学模型方法研究糖皮质激素对于关节肿胀和骨损害的影响,并整合了这三个关键炎症因子的定量影响,但目前缺少单一炎症因子对关节肿胀和骨损害的定量影响研究.
逍遥散始载于《太平惠民和剂局方》,是治疗抑郁症的千古名方.近年来,在动物实验和临床试验中多次表明逍遥散具有显著的抗抑郁作用,但是应用1H NMR代谢组学技术结合多元统计分析方法从整体上阐明抑郁症的发病机制以及逍遥散的抗抑郁作用机制的相关文献报道较少.本文应用1H NMR代谢组学技术结合偏最小二乘判别分析法(PLS-DA)和正交偏最小二乘判别分析法(OPLS-DA)分别分析抑郁症患者以及抑郁症患者治
目的:结肠癌的发病率及死亡率在我国呈逐年上升的趋势,且趋于年轻化.部分患者在确诊结肠癌时已发生肝转移,约60％～71％的结肠癌患者最终发生肝转移导致死亡.大量研究证实结肠癌干细胞是导致结肠癌发生发展、转移复发、放化疗抵抗的源泉.目前,靶向结肠癌干细胞的治疗还没有取得突破性进展.5-氟尿嘧啶(5-Fu)是结肠癌化疗的常用药物,然而5-Fu毒副反应大限制了其在临床的广泛应用.普朗尼克(Pluronic