枸杞多糖LBPF4-OL免疫调节靶细胞及活性相关受体研究

来源 :2014年全国糖生物学学术会议 | 被引量 : 0次 | 上传用户：plutus001

【摘要】

：

枸杞多糖的免疫调节作用已经有很多报道,但是其免疫调节靶细胞及活性相关受体尚未阐明.本研究通过与化学密切合作,获得了枸杞多糖蛋白复合物LBPF4及枸杞多糖LBPF4-OL,并分析

【作者】

：

张小锐王仲俘黄琳娟周文霞张永祥

【机构】

：

北京毒物药物研究所,北京100850西北大学生命科学院,陕西西安,710069

【出处】

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2014年全国糖生物学学术会议

【发表日期】

：

2014年7期

【关键词】

：

枸杞多糖免疫调节巨噬细胞 TLR4/MD2 MAPK

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枸杞多糖的免疫调节作用已经有很多报道,但是其免疫调节靶细胞及活性相关受体尚未阐明.本研究通过与化学密切合作,获得了枸杞多糖蛋白复合物LBPF4及枸杞多糖LBPF4-OL,并分析了LBPF4-OL的初级结构,进而采用淋巴细胞增值、磁性免疫细胞分选、ELISA、流式细胞术(FCM)等免疫药理学实验技术观察了枸杞多糖蛋白复合物LBPF4及枸杞多糖LBPF4-OL的免疫活性的差异,明确了LBPF4-OL的免疫调节靶细胞,并阐明了枸杞多糖的活性相关受体及其信号通路.

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枸杞多糖LBPF4-OL免疫调节靶细胞及活性相关受体研究

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