The advent of dentin bonding has revolutionarized restorative dentistry.Dentists are currently using etch-and-rinse and self-etch adhesives to bond tooth-colored restorative materials to tooth substrates.However, current generations of dentin adhesives are not as durable as they were previously thought.In this lecture, the reasons for this lack of durability and the existing and experimental methods of increasing the bond longevity will be discussed.These methods include the application of matrix metalloproteinase inhibitors to resin-dentin interfaces, ethanol wet bonding and biomimetic remineralization of resin-dentin bonds.