【摘 要】
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A number of research groups have attempted to determine the absolute configuration of(+)-mefloquine hydrochloride since 1974.Very surprisingly,its absolute configuration is controversial for nearly 40
【机 构】
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School of Pharmacy,Fourth Military Medical University,169 Changle West Road,Xi'an 710032,P.R.China
【出 处】
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全国药物化学学术会议暨第四届中英药物化学学术会议
论文部分内容阅读
A number of research groups have attempted to determine the absolute configuration of(+)-mefloquine hydrochloride since 1974.Very surprisingly,its absolute configuration is controversial for nearly 40 years:having the assignment of(+)-(11R,12S)six times and of(-)-(11R,12S)three times! We have synthesized stereospecifically(-)-erythro-mefloquine hydrochloride from commercial available(S)-(-)-1-Boc-2-piperidinecarboxylic acid in four steps without affecting the chiral center and unambiguously determined its absolute configuration as(11R,12S).
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