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Ti matrix syntactic foams have potential for orthopaedic applications, because of their good biocompatibility, corrosion resistance and ability of varying the elastic modulus.Previous study conducted a research on the Ti matrix syntactic foam embedded with thin wall ceramic microspheres (CMs).Using thin wall CMs can result crushed CMs during the compaction procedure.The crushed CMs can affect the elastic modulus of Ti matrix syntactic foam.To overcome the disadvantages of thin wall CMs (low strength), a thick wall CMs with higher strength was embedded into Ti matrix instead of thin wall CMs.This paper studies the fabrication of Ti matrix syntactic foams embedded with thick wall ceramic microspheres by a powder metallurgy method.The structure, compressive behaviour and elastic modulus of Ti matrix syntactic foam embedded with thick wall CMs were analyzed and compared with those embedded with thin wall CMs.Results show that using thick wall CMs can increase the compressive strength obviously.Increase of the volume percentage of CMs can increase the compressive strength of Ti matrix syntactic foam clearly.The elastic moduli were similar with those of human bone.Compared with Ti matrix syntactic foam embedded with thin wall CMs, Using thick wall CMs can increase the compressive strength without increase the elastic modulus significantly.