【摘 要】
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Differentiation of oligodendrocyte precursor cells (OPCs) is a prerequisite for both developmental myelination and adult remyelination in the central nervous system.The molecular mechanisms underlying
【出 处】
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华东地区第十四届实验动物科学学术交流会
论文部分内容阅读
Differentiation of oligodendrocyte precursor cells (OPCs) is a prerequisite for both developmental myelination and adult remyelination in the central nervous system.The molecular mechanisms underlying OPC differentiation remain largelyunknown.Here,we show that the thirty-kDa HIV-1 Tat interacting protein (TIP30) is a negative regulator in oligodendrocyte development.The TIP302/2 mice displayed an increased myelin protein level at postnatal day 14 and 21.
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