肝X受体通过调控内质网应激通路减弱由缺氧复氧损伤诱导的H9c2心肌细胞凋亡

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户：konashu

【摘要】

：

目的:观察肝X受体对由缺氧复氧损伤诱导的H9c2心肌细胞凋亡的影响,并测定内质网应激凋亡通路相关指标的变化,初步阐明肝X受体在内质网应激水平对H9c2心肌细胞凋亡过程中的作用.方法:1.体外培养大鼠H9c2心肌细胞,进行缺氧3h复氧10h,复制缺氧复氧模型,并随机分为3组,正常对照组(Control组)、缺氧/复氧组(H/R)、T0901317 (10μ mol/L)预处理+缺氧/复氧组.

【作者】

：

刘喜雷殷然彭景添

【机构】

：

南昌大学第一附属医院心内科

【出处】

：

第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int

【发表日期】

：

2013年2期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

NARROWING QRS COMPLEX BY BIVENTRICULAR PACING COMBINING AV NODE INTRINSIC CONDUCTION IN PATIENTS WIT

Objectives To evaluate the impact of biventricular pacing combining AV node intrinsic conduction (the combination mode) on width of QRS complex in patients with cardiac resynchronisation therapy (CRT)

会议

CLINICAL OBSERVATION OF ACAPTMCOMFIRM IN ZEPHYR5826 PACEMAKER

Objectives To observe the atrial capture management in Zephyr5826 pacemaker.By calculating the open rate of ACapTMcomfirm in different circumstances and comparing atrial thresholds measured automatica

会议

ELECTROPHYSIOLOGICAL CHARACTERISTIC AND ABLATION OF EPICARDIAL IDIOPATHIC VENTRICULAR ARRHYTHMIAS AR

Objectives The success rate of radiofrequency catheter ablation of ventricular arrhythmias originating from left fibrous triangle (LFT) is not high.This article was to discuss the characteristics of s

会议

CARTO THREE-DIMENSIONAL MAPPING SYSTEM GUIDED CATHETER ABLATION OF MACRO-REENTRANT ATRIAL TACHYCARDI

Objectives Because radiofrequency catheter ablation of macroreentrant atrial tachycardia (AT) following cardiac surgery of structural heart disease had a low successful rate and a high recurrence, we

会议

THE COMPARISON BETWEEN THE ACTIVE-FIXATION LEADS AND PASSIVE-FIXATION LEADS IN RIGHT VENTRICULAR API

Objectives More and more active-fixation leads were used in the implantation of pacemaker, but compared with the traditional passive-fixation leads, the differences of the pacing parameter were not cl

会议

LONG-TERM PERFORMANCE OF ACTIVE FIXATION PACING LEADS IN RIGHT ATRIUM

Objectives More and more active-fixation leads were used in the right atrium during the implantation of pacemaker, the aim of this study was to explore the feasibility of active-fixation right atrial

会议

CORRELATION OF CHADS2 AND CHA2DS2-VASC SCORES WITH LEFT ATRIAL THROMBUS IN CHINESE PATIENTS WITH NON

Objectives The aims of this study were to evaluate the relationship of the CHADS2 and CHA2DS2-VASc scores with left atrial (LA) thrombus detected by transesophageal echocardiographic and to compare th

会议

阿托伐他汀通过上调PGC-1a表达抑制TNF-a诱导的心肌细胞葡萄糖氧化率增加

目的:最近的研究表明阿托伐他汀具有抗炎效果的同时还能够阻止心肌肥厚.在心肌肥厚和心功能紊乱时心肌细胞的葡萄糖氧化率是增高的.本篇文章我们报道了,在炎症因子刺激心肌细胞时心肌细胞的葡萄糖氧化率是增加的,阿托伐他汀能抑制葡萄糖氧化率的增加,阿托伐他汀的这种抑制作用是通过上调PGC-1a实现的.

会议

血管紧张素Ⅱ及甘松提取物对人心房肌细胞内游离钙浓度及心房电重构的影响

目的:从心房肌细胞钙浓度改变的角度,探索血管紧张素Ⅱ及甘松提取物对人心房肌细胞电重构的影响.方法:选取正常及心房颤动(房颤)患者的右心耳组织,进行心房肌细胞的分离、培养、鉴定,分别予血管紧张素Ⅱ、甘松提取物干预,测定其细胞内钙离子浓度,进行对比分析.

会议

西洋参茎叶总皂苷对阿司匹林和氯吡格雷联合致大鼠胃黏膜损伤的修复作用

目的:双抗(阿司匹林和氯吡格雷联合)对胃黏膜的损伤,是冠心病一、二级预防普遍关注的问题.本文旨在观察西洋参茎叶总皂苷(Panax quinquefolius Saponin,PQS)在双抗治疗过程中对胃黏膜损伤的修复作用.方法:36只SD大鼠,采用结扎左冠状动脉前降支制备实验性急性心肌梗死(Acute Myocardial Infarction,AMI)模型.将手术成功大鼠按随机数字表分为AMI模

会议

肝X受体通过调控内质网应激通路减弱由缺氧复氧损伤诱导的H9c2心肌细胞凋亡

与本文相关的学术论文