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This study was aimed to assess remyelination and axon regeneration of compounds using Hunter Biotechs zebrafish MS models.Zebrafish at 2 day post fertilization (2 dpf) were treated with demyelinating agent ethidium bromide (EB) for 72 hours (hrs) to induce demyelination.After removing EB,demyelinated zebrafish were treated with test compounds for another 24 hrs;Compound effect on demyelination-associated motility was assessed using a video-track motion detector.We found that compounds 2 and 9 recovered motility in EB-induced demyelinated zebrafish;whereas compounds 2 and 9 had significant effect on motility.